Comparative Ophthalmology, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Small Animal Surgery, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Vet Ophthalmol. 2021 Mar;24 Suppl 1:116-124. doi: 10.1111/vop.12800. Epub 2020 Jul 1.
To explore the effects of chronic, uncontrolled glaucoma on pressure sensitivity in dogs before and after enucleation of the painful globe.
Client-owned dogs undergoing enucleation for chronic glaucoma with no other sources of pain were enrolled. Normal dogs of similar breeds and skull morphology were enrolled as controls. Craniofacial ratio (CFR) and relative palpebral fissure width (RPFW) were assessed in all patients. Serial mechanical quantitative sensory testing (QST) was performed the day before surgery, and 14, 30, 60, and 120 days after surgery. QST consisted of electronic Von Frey (eVF), and blunt algometry (BA) performed above and below the nonglaucomatous eye, the metacarpus, and metatarsus. Cochet-Bonnet esthesiometry (CB) was also performed on the remaining eye.
Twelve dogs (6 per group) were included. Compared to baseline values, sensitivity tended to decrease over time (increased thresholds) in treatment dogs while it stayed constant or increased slightly in control dogs. The difference in change from baseline sensitivity between control and treatment groups was significant at day 120 using BA at supraorbital (P = .0153), infraorbital (P = .0209), and metacarpal sites (P = .007) and overall (P = .0470). This divergence was also significant using CB (P = .0470) on the opposite cornea. As patient CFR and RPFWV increased, both eVF (P = .005-.023) and BA (P = .004-.041) increased.
Sensitivity to mechanical stimuli decreased both locally and at remote sites in dogs following enucleation for painful chronic glaucoma. Cranial conformation is associated with differences in sensitivity.
探讨慢性、未控制的青光眼对眼球摘除前后犬压力敏感性的影响。
纳入因慢性青光眼而接受眼球摘除且无其他疼痛源的患犬。纳入具有相似品种和颅骨形态的正常犬作为对照组。所有患者均进行颅面比（CFR）和相对睑裂宽度（RPFW）评估。在手术前 1 天及手术后 14、30、60 和 120 天进行连续机械定量感觉测试（QST）。QST 包括电子 von Frey（eVF）和钝性压痛计（BA），分别在非青光眼侧的上方和下方、掌骨和跖骨上进行。还对剩余的眼睛进行 Cochet-Bonnet 触觉计（CB）测量。
纳入 12 只犬（每组 6 只）。与基线值相比，治疗犬的敏感性随时间推移呈下降趋势（阈值升高），而对照组犬的敏感性保持不变或略有升高。在眶上（P=.0153）、眶下（P=.0209）和掌骨部位（P=.007）以及整体（P=.0470）的 BA 测量中，控制组和治疗组从基线敏感性变化的差异在术后 120 天具有统计学意义。在对侧角膜的 CB 测量中也有显著差异（P=.0470）。随着患者 CFR 和 RPFWV 的增加，eVF（P=.005-.023）和 BA（P=.004-.041）均增加。
眼球摘除治疗疼痛性慢性青光眼后，犬的局部和远处机械刺激敏感性均下降。颅面形态与敏感性差异有关。
