Abteilung für Gastroenterologie und Hepatologie, Universitätsklinik für Innere Medizin 3, Medical University of Vienna, Vienna, Austria.
Department of Paediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Neurogastroenterol Motil. 2020 Dec;32(12):e13934. doi: 10.1111/nmo.13934. Epub 2020 Jul 1.
There is an unmet need for a validated, test-specific symptom questionnaire to evaluate carbohydrate perception during breath tests. Our aim was to develop and validate a questionnaire for the assessment of symptoms after a provocative carbohydrate load.
After a literature search and initial focus group-style interviews, five relevant complaints were identified. Responses were given on a Likert-type faces scale with a language children use and understand. Reliability, validity and responsiveness to change were established by the implementation of the questionnaire during breath tests in 215 pediatric subjects. Correlation between the questionnaire and a medical interview by a pediatrician who was blinded to the results of the questionnaire (n = 19) was determined.
The questionnaire had good face and content validity (Lawshe ratio = 1). Intraclass correlation coefficients for test-retest reliability (n = 116) demonstrated good repeatability (P < .001), and effect sizes were small (Cohen's d < 0.15 for all symptoms). Convergent validity and discriminant validity were supported according to the multitrait-multimethod matrix method. The results obtained by the questionnaire correlated highly with the result of the medical interview (P < .001; Fisher's exact test). Cronbach's alpha was 0.81. Responsiveness was verified for the whole patient group and subgroups with medium to high effect sizes.
The paediatric Carbohydrate Perception Questionnaire (pCPQ) is a simple, test-specific questionnaire for a pediatric population. It is a valid instrument with excellent psychometric properties to assess gastrointestinal symptoms after carbohydrate ingestion. The pCPQ can replace non-validated symptom assessment during carbohydrate breath tests and allows a standardized diagnosis of carbohydrate intolerance.
目前需要一种经过验证的、针对特定测试的症状问卷，以评估呼吸试验期间碳水化合物的感知情况。我们的目的是开发和验证一种用于评估刺激性碳水化合物负荷后症状的问卷。
在文献检索和初步焦点小组式访谈后，确定了五个相关的投诉。使用儿童使用和理解的语言，通过李克特式脸谱量表给出答案。通过在 215 名儿科患者的呼吸试验中实施问卷，确定了问卷的可靠性、有效性和对变化的反应能力。问卷与一名对问卷结果一无所知的儿科医生进行的医学访谈之间的相关性（n=19）也进行了确定。
该问卷具有良好的表面和内容效度（劳什比率=1）。对 116 例测试-再测试的内部一致性系数表明，可重复性良好（P<0.001），所有症状的效应量均较小（Cohen's d<0.15）。根据多特质-多方法矩阵法，支持了收敛有效性和判别有效性。问卷的结果与医学访谈的结果高度相关（P<0.001；Fisher 确切检验）。克朗巴赫的α值为 0.81。整个患者组和具有中高效应量的亚组的反应性得到了验证。
儿科碳水化合物感知问卷（pCPQ）是一种针对儿科人群的简单、特定于测试的问卷。它是一种具有优异心理测量特性的有效工具，可用于评估碳水化合物摄入后胃肠道症状。pCPQ 可以替代碳水化合物呼吸试验中未经验证的症状评估，并允许对碳水化合物不耐受进行标准化诊断。
