Department of Public Health Programmes, Regional Hospital Randers, Randers, Denmark.
Department of Clinical Medicine, Aarhus University, aarhus, Denmark.
Cancer Med. 2020 Aug;9(16):6042-6050. doi: 10.1002/cam4.3182. Epub 2020 Jun 30.
Breast cancer survivors are increasing followed for new breast cancers / recurrences by mammography screening only. We aimed at assessing how often breast cancer survivors get a false positive or false negative result at mammography screening.
All mammography screenings performed between 2007 and 2017 in the Danish national mammography screening programme were included. Screenings in women with a breast cancer diagnosis prior to invitation were included in the "breast cancer survivors" group, while remaining screenings were included in the "no previous breast cancer" group. We compared the proportion of false positive screenings and the proportion of breast cancers detected at screening among breast cancer survivors and women without previous breast cancer. The analyses were further stratified according to whether the women had a diagnostic breast imaging in the 21 months prior to the screening.
At initial screenings, breast cancer survivors had a significant lower false positive risk than other women, while the risk was similar at subsequent screenings. Breast cancer survivors had a significant lower proportion of breast cancers detected at screening compared to other women. This was true both for women who had a diagnostic breast imaging in the 21 months prior to screening and those who did not.
This study shows that breast cancers survivors have a smaller amount of their new breast cancers detected at mammography screening, when compare to the amount of new breast cancers detected at mammography screening among women without previous breast cancer. The lower sensitivity does not seem to be due to different behavior among breast cancer survivors.
越来越多的乳腺癌幸存者仅通过乳房 X 光筛查来追踪新的乳腺癌/复发情况。我们旨在评估乳腺癌幸存者在乳房 X 光筛查中假阳性或假阴性的结果出现频率。
纳入了 2007 年至 2017 年间在丹麦全国乳房 X 光筛查计划中进行的所有乳房 X 光筛查。在邀请前被诊断患有乳腺癌的女性的筛查被纳入“乳腺癌幸存者”组，而其余的筛查则被纳入“无既往乳腺癌”组。我们比较了乳腺癌幸存者和无既往乳腺癌女性的假阳性筛查比例和筛查中检出的乳腺癌比例。分析还根据女性在筛查前 21 个月是否进行了诊断性乳房成像进行了分层。
在初始筛查中，乳腺癌幸存者的假阳性风险显著低于其他女性，而在后续筛查中风险相似。与其他女性相比，乳腺癌幸存者在筛查中检测到的乳腺癌比例显著较低。这对于在筛查前 21 个月进行过诊断性乳房成像的女性和未进行过诊断性乳房成像的女性都是如此。
本研究表明，与无既往乳腺癌女性相比，乳腺癌幸存者在乳房 X 光筛查中检测到的新乳腺癌数量较少。这种较低的敏感性似乎不是由于乳腺癌幸存者的不同行为所致。
