Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA.
Nat Prod Rep. 2020 Dec 16;37(12):1661-1699. doi: 10.1039/d0np00025f.
Covering: 2015 to up to 2019 This review presents the recent progress towards elucidating the structures of chiral natural products and applications using vibrational optical activity (VOA) spectroscopy. Vibrational circular dichroism (VCD) and vibrational Raman optical activity (VROA) are two separate branches of VOA spectroscopy, providing independent and complementary structural information. While determining the absolute configuration (AC) of a given natural product is the primary goal, the determination or assessment of major conformations associated with each diastereomer is also a significant part of this enquiry. The latest developments in experimental and computational aspects of VOA spectroscopies and their applications for inferring the AC and predominant conformations of natural products are summarized. The prospects and limitations in the application of VOA spectroscopy to new natural products are summarized.
2015 年至 2019 年 本综述介绍了近年来在阐明手性天然产物结构和应用方面的最新进展，使用了振动圆二色性（VCD）和振动拉曼光学活性（VROA）光谱技术。VCD 和 VROA 是 VOA 光谱学的两个分支，提供了独立且互补的结构信息。虽然确定给定天然产物的绝对构型（AC）是主要目标，但确定或评估与每个非对映异构体相关的主要构象也是该研究的重要部分。总结了 VOA 光谱学的实验和计算方面的最新进展及其在手性天然产物 AC 和主要构象推断中的应用。总结了 VOA 光谱学在手性天然产物中的应用前景和局限性。
