从根皮中分离得到的抗菌二氢黄酮醇和异黄酮。

Antimicrobial Dihydroflavonols and Isoflavans Isolated from the Root Bark of .

机构信息

Department of Chemistry, University of Nairobi, P.O. BOX 30197, 30197-00100 Nairobi, Kenya.

Department of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden.

出版信息

J Nat Prod. 2024 Sep 27;87(9):2263-2271. doi: 10.1021/acs.jnatprod.4c00690. Epub 2024 Sep 10.

DOI:10.1021/acs.jnatprod.4c00690

PMID:39255387

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11443528/

Abstract

Three new dihydroflavonols, gloverinols A-C (-), a new flavon-3-ol, gloverinol D (), two new isoflavans, gloveriflavan A () and B (), and seven known compounds were isolated from the root bark of . The structures of the isolates were elucidated by using NMR, ECD, and HRESIMS data analyses. Among the isolated compounds, gloverinol B (), gloveriflavan B (), and 1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4-hydroxyphenyl)-1-propanone () were the most active against , with MIC values of 9.2, 18.4, and 14.2 μM, respectively.

摘要

从地构叶根皮中分离得到三个新的二氢黄酮醇（gloverinols A-C（-））、一个新的黄酮醇（gloverinol D（））、两个新的异黄烷（gloveriflavan A（）和 B（））和七个已知化合物。通过 NMR、ECD 和 HRESIMS 数据分析阐明了这些分离物的结构。在所分离的化合物中，gloverinol B（）、gloveriflavan B（）和 1-(2,4-二羟基苯基)-3-羟基-3-(4-羟基苯基)-1-丙酮（）对活性最强，MIC 值分别为 9.2、18.4 和 14.2 μM。