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The studies of the mechanism of antiinflammatory action of 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043).

作者信息

Ito K, Kagaya H, Satoh I, Tsukamoto G, Nose T

出版信息

Arzneimittelforschung. 1982;32(2):117-22.

PMID:6950724
Abstract

The mechanism of the antiinflammatory activity of 2-(5-ethylpyridin-2-ly)benzimidazole (KB-1043), a new benzimidazole derivative with antiinflammatory, analgesic and antipyretic activities, is described. KB-1043 inhibits the emigration of leucocytes and the exudation of protein into the site of injury. KB-1043 possesses also a potent membrane stabilizing activity. Although KB-1043, in vitro, did not inhibit the enzyme activity, the increase of enzyme activity at the site of injury was inhibited by the oral administration of KB-1043. The inhibitory effect of KB-1043 on prostaglandin synthesis was slightly weaker than that of acetylsalicylic acid (ASA). The antiinflammatory effect of DB-1043 was observed also in adrenalectomized rats and spinalectomized rats.

摘要

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2
In vitro metabolism of 2-(5-ethylpyridin-2-yl)benzimidazole.
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3
In vivo metabolism of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole.
Eur J Drug Metab Pharmacokinet. 1989 Oct-Dec;14(4):263-8. doi: 10.1007/BF03190109.