Lian Jie, Li Yi-Fei, Wang Xiao-Xuan, Ye Bin, Zou Hua, Shi Hong-Xing
School of Environmental and Civil Engineering, Jiangnan University, Wuxi 214122, China.
Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou 215009, China.
Huan Jing Ke Xue. 2020 May 8;41(5):2229-2238. doi: 10.13227/j.hjkx.201909233.
Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drug residues with a high frequency of detection in Taihu Lake. However, little information is available about the occurrence of typical NSAID mixtures in Taihu Lake as a whole across the four seasons. Therefore, for each season, the concentrations of five typical NSAIDs including diclofenac, ibuprofen, indomethacin, naproxen, and ketoprofen were monitored in the water of Taihu Lake by the method of high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS) at 19 transects covering the entire lake. The temporal and spatial occurrence of NSAID mixtures in the water of Taihu Lake and their correlation with environmental factors were analyzed, and the mixture risk quotient (MRQ) model was also used to assess the ecological risk of the NSAID mixtures. The research results are as follows:① The concentrations of NSAIDs in the northern, western, and eastern waters of Taihu Lake are at a higher level compared to those in the central waters. Ketoprofen is the main contributor to the contamination of NSAID mixtures in all regions of Taihu Lake. ② The concentrations of NSAIDs in Taihu Lake are higher in summer (15.9-134.3 ng·L) and autumn (16.4-144.6 ng·L) but lower in spring (25.3-72.5 ng·L) and winter (14.6-57.4 ng·L), being significantly correlated with water conductivity and pH, respectively. ③ The MRQ model evaluation reveals that there are nine sections in Taihu Lake showing a high ecological risk (MRQ>1) from NSAID mixtures throughout the year. The ecological risk of the NSAID mixtures at a medium or high level (MRQ>0.1) lasts for a long time spanning the spring, summer, and autumn seasons, of which the risk is greatest in autumn. Overall, the pollution caused by the NSAID mixtures in the water of Taihu Lake should not be ignored, and especially great attention should be paid to the pollution in autumn.
非甾体抗炎药（NSAIDs）是太湖中检测频率较高的一类药物残留。然而，关于太湖全湖四季典型非甾体抗炎药混合物的出现情况，目前所知甚少。因此，针对每个季节，采用高效液相色谱 - 质谱联用（HPLC - MS/MS）法，在覆盖太湖全湖的19个断面监测了双氯芬酸、布洛芬、吲哚美辛、萘普生和酮洛芬这五种典型非甾体抗炎药在太湖水体中的浓度。分析了太湖水体中非甾体抗炎药混合物的时空分布及其与环境因素的相关性，还采用混合物风险商（MRQ）模型评估了非甾体抗炎药混合物的生态风险。研究结果如下：① 太湖北部、西部和东部水域的非甾体抗炎药浓度高于中部水域。酮洛芬是太湖各区域非甾体抗炎药混合物污染的主要贡献者。② 太湖中非甾体抗炎药的浓度在夏季（15.9 - 134.3 ng·L）和秋季（16.4 - 144.6 ng·L）较高，而在春季（25.3 - 72.5 ng·L）和冬季（14.6 - 57.4 ng·L）较低，分别与水体电导率和pH值显著相关。③ MRQ模型评估显示，太湖全年有9个断面呈现出较高的非甾体抗炎药混合物生态风险（MRQ>1）。非甾体抗炎药混合物中、高生态风险水平（MRQ>0.1）持续时间较长，跨越春、夏、秋三季，其中秋季风险最大。总体而言，太湖水体中非甾体抗炎药混合物造成的污染不容忽视，尤其应高度关注秋季的污染情况。
