实验性利什曼病中L3T4 + T细胞对多克隆B细胞的刺激作用
Polyclonal B-cell stimulation by L3T4+ T cells in experimental leishmaniasis.
作者信息
Lohoff M, Matzner C, Röllinghoff M
机构信息
Institut für Klinische Mikrobiologie, Universität Erlangen-Nürnberg, Federal Republic of Germany.
出版信息
Infect Immun. 1988 Aug;56(8):2120-4. doi: 10.1128/iai.56.8.2120-2124.1988.
Abstract
The well-established polyclonal B-cell stimulation in the lymphoid organs in mice infected with Leishmania major is thought to be dependent on T cells. Here we present clear experimental evidence that this is indeed the case by showing that BALB/c-derived, L3T4-positive L. major-specific T cells induce syngeneic B cells to polyclonal proliferation and immunoglobulin production.
摘要
在感染硕大利什曼原虫的小鼠的淋巴器官中，早已确定的多克隆B细胞刺激被认为依赖于T细胞。在此，我们通过展示源自BALB/c的、L3T4阳性的硕大利什曼原虫特异性T细胞诱导同基因B细胞进行多克隆增殖和免疫球蛋白产生，给出了明确的实验证据证明确实如此。
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