实验性利什曼病中L3T4 + T细胞对多克隆B细胞的刺激作用
Polyclonal B-cell stimulation by L3T4+ T cells in experimental leishmaniasis.
作者信息
Lohoff M, Matzner C, Röllinghoff M
机构信息
Institut für Klinische Mikrobiologie, Universität Erlangen-Nürnberg, Federal Republic of Germany.
出版信息
Infect Immun. 1988 Aug;56(8):2120-4. doi: 10.1128/iai.56.8.2120-2124.1988.
Abstract
The well-established polyclonal B-cell stimulation in the lymphoid organs in mice infected with Leishmania major is thought to be dependent on T cells. Here we present clear experimental evidence that this is indeed the case by showing that BALB/c-derived, L3T4-positive L. major-specific T cells induce syngeneic B cells to polyclonal proliferation and immunoglobulin production.
摘要
在感染硕大利什曼原虫的小鼠的淋巴器官中，早已确定的多克隆B细胞刺激被认为依赖于T细胞。在此，我们通过展示源自BALB/c的、L3T4阳性的硕大利什曼原虫特异性T细胞诱导同基因B细胞进行多克隆增殖和免疫球蛋白产生，给出了明确的实验证据证明确实如此。
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本文引用的文献
1
Role of the major histocompatibility complex in T cell activation of B cell subpopulations. A single monoclonal T helper cell population activates different B cell subpopulations by distinct pathways.主要组织相容性复合体在B细胞亚群T细胞活化中的作用。单一的单克隆辅助性T细胞群体通过不同途径激活不同的B细胞亚群。
J Exp Med. 1982 Aug 1;156(2):350-60. doi: 10.1084/jem.156.2.350.
2
Leishmania tropica: association of a B-cell mitogen with hypergammaglobulinemia in mice.热带利什曼原虫：小鼠中一种B细胞促有丝分裂原与高丙种球蛋白血症的关联。
Exp Parasitol. 1982 Feb;53(1):87-96. doi: 10.1016/0014-4894(82)90095-9.
3
Polyclonal B cell activation in hamsters infected with parasites of the genus Leishmania.感染利什曼原虫属寄生虫的仓鼠中的多克隆B细胞激活。
Infect Immun. 1982 Dec;38(3):871-6. doi: 10.1128/iai.38.3.871-876.1982.
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Polyclonal B cell activation, circulating immune complexes and autoimmunity in human american visceral leishmaniasis.人类美洲内脏利什曼病中的多克隆B细胞激活、循环免疫复合物与自身免疫
Clin Exp Immunol. 1984 Apr;56(1):58-66.
5
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Antigen-specific helper T-cell clone supernatant is sufficient to induce both polyclonal proliferation and differentiation of small resting B lymphocytes.抗原特异性辅助性T细胞克隆上清液足以诱导静止的小B淋巴细胞发生多克隆增殖和分化。
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7
Polyclonal stimulation of resting B lymphocytes by antigen-specific T lymphocytes.抗原特异性T淋巴细胞对静止B淋巴细胞的多克隆刺激。
J Exp Med. 1984 Mar 1;159(3):861-80. doi: 10.1084/jem.159.3.861.
8
The in vitro generation and functional analysis of murine T cell populations and clones specific for a protozoan parasite, Leishmania tropica.
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9
Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo.通过体内消除T细胞亚群进行单克隆抗体治疗。
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10
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