人类美洲内脏利什曼病中的多克隆B细胞激活、循环免疫复合物与自身免疫
Polyclonal B cell activation, circulating immune complexes and autoimmunity in human american visceral leishmaniasis.
作者信息
Galvão-Castro B, Sá Ferreira J A, Marzochi K F, Marzochi M C, Coutinho S G, Lambert P H
出版信息
Clin Exp Immunol. 1984 Apr;56(1):58-66.
Abstract
In a prospective study, serum and plasma samples from 17 patients with kala-azar were collected in Rio de Janeiro. High levels of immune complexes (IC) were detected in serum by means of 125I-Clq and conglutinin binding assays. The Clq binding material had a sedimentation coefficient of 19-25S, as determined by ultracentrifugation on sucrose gradient. Plasma levels of C3 and C3 breakdown products were measured and the C3d levels were increased in six out of 11 patients. The occurrence of polyclonal B cell activation was suggested by (a) a marked increase of serum IgG and IgM levels and (b) of the presence of antibodies against various proteins and haptens (SRBC, DNP-BSA, FITC-BSA,KLH). There was a close association between the presence of IC and anti-immunoglobulin antibodies. Anti-smooth muscle antibodies were also observed. These data are consistent with a major role of polyclonal B cell activation in the induction of IC during visceral leishmaniasis.
摘要
在一项前瞻性研究中，从里约热内卢的17名黑热病患者身上采集了血清和血浆样本。通过125I-Clq和胶固素结合试验检测到血清中存在高水平的免疫复合物（IC）。通过在蔗糖梯度上进行超速离心测定，Clq结合物质的沉降系数为19 - 25S。测量了血浆中C3和C3裂解产物的水平，11名患者中有6名患者的C3d水平升高。（a）血清IgG和IgM水平显著升高以及（b）存在针对各种蛋白质和半抗原（绵羊红细胞、二硝基苯 - 牛血清白蛋白、异硫氰酸荧光素 - 牛血清白蛋白、钥孔戚血蓝蛋白）的抗体，提示多克隆B细胞活化的发生。IC的存在与抗免疫球蛋白抗体之间存在密切关联。还观察到抗平滑肌抗体。这些数据与多克隆B细胞活化在内脏利什曼病中诱导IC的主要作用一致。
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