State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China.
Food Funct. 2020 Jul 22;11(7):6363-6375. doi: 10.1039/d0fo01017k.
Red yeast rice (RYR), a traditional Chinese fermented food, has the effect of lowering blood lipid and cholesterol, but little information is available about whether RYR can inhibit pathogenic bacterial infection in vivo. The present study explored the effect of RYR on Salmonella enterica-induced intestinal inflammation and gut microbiota dysbiosis in mice as well as the underlying anti-inflammatory mechanism. Results showed that RYR can alleviate S. enterica infection in vivo and Monascus pigments are the main functional components. The analysis of microbiota, gene expression profile and serological immunology revealed that RYR can regulate the intestinal flora and increase the relative abundance of beneficial bacteria such as Lactobacillus and Akkermansia. Meanwhile, RYR is also found to regulate the expression of pro-inflammatory factors and tight junction-related genes to inhibit the NO and NF-κB-mediated inflammatory response and maintain the integrity of the intestinal barrier. This study provides a new dietary intervention strategy for the prevention of pathogenic bacterial infection.
红曲米（RYR）是一种传统的中国发酵食品，具有降低血脂和胆固醇的作用，但关于 RYR 是否能抑制体内致病菌感染的信息较少。本研究探讨了 RYR 对鼠伤寒沙门氏菌诱导的肠道炎症和肠道微生物失调的影响及其潜在的抗炎机制。结果表明，RYR 可减轻体内鼠伤寒沙门氏菌感染，其中红曲色素是主要的功能成分。微生物分析、基因表达谱和血清免疫学分析表明，RYR 可调节肠道菌群，增加有益菌如乳杆菌和阿克曼氏菌的相对丰度。同时，RYR 还被发现可调节促炎因子和紧密连接相关基因的表达，抑制 NO 和 NF-κB 介导的炎症反应，维持肠道屏障的完整性。本研究为预防致病菌感染提供了一种新的饮食干预策略。
