Pierote Josué Junior Araujo, Prieto Lucia Trazzi, Dias Carlos Tadeu Dos Santos, CÂmara João Victor Frazão, Lima Débora Alves Nunes Leite, Aguiar Flávio Henrique Baggio, Paulillo Luis Alexandre Maffei Sartini
Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba, Departamento de Dentística Restauradora, Piracicaba, Brasil.
Universidade de São Paulo, Escola Superior de Agricultura Luiz de Queiroz, Departamento de Engenharia Agronômica, Piracicaba, Brasil.
J Appl Oral Sci. 2020 Jun 24;28:e20190755. doi: 10.1590/1678-7757-2019-0755. eCollection 2020.
To clinically assess the effect of desensitizing gels and dentifrices on the reduction in pain sensitivity and color variation during tooth bleaching.
A total of 108 volunteers were randomly separated into the following groups of n=12: GT/S-glycerine and thickener/sucralose; NF/S-potassium nitrate and sodium fluoride/sucralose; NA/S-potassium nitrate and arginine/sucralose; GT/AC-glycerine and thickener/arginine and calcium carbonate; NF/AC-potassium nitrate and sodium fluoride/arginine and calcium carbonate; NA/AC-potassium nitrate and arginine/arginine and calcium carbonate; GT/PN-glycerine and thickener/potassium nitrate; NF/PN-potassium nitrate and sodium fluoride/potassium nitrate; and NA/PN-potassium nitrate and arginine/potassium nitrate. Sensitivity was assessed with the numerical analogue scale, and color variation (ΔE) was measured with a spectrophotometer. The sensitivity values obtained were subjected to a multivariate analysis of variance (MANOVA) and color variation values were subjected to a randomized analysis of variance (p<0.05).
The NF/AC, NA/AC, NF/PN, and NA/PN groups presented lower sensitivity values and reduced sensitivity compared to those of the other groups throughout the clinical sessions. None of the groups showed sensitivity at the 24-week assessment. Statistically, no significant difference were observed in the color values among the groups four weeks after the beginning of bleaching (p=0.074). Additionally, the color assessment of all groups was statistically similar four weeks (p=0.084) and 24 weeks (p=0.118) after the beginning.
Our results indicate that adding NF/S, NA/S, NF/AC, and NA/AC desensitizers to tooth bleaching protocols reduces pain sensitivity without affecting its effectiveness.
临床评估脱敏凝胶和牙膏对牙齿漂白过程中疼痛敏感度降低及颜色变化的影响。
总共108名志愿者被随机分为以下每组12人的几组：GT/S组——甘油和增稠剂/三氯蔗糖；NF/S组——硝酸钾和氟化钠/三氯蔗糖；NA/S组——硝酸钾和精氨酸/三氯蔗糖；GT/AC组——甘油和增稠剂/精氨酸和碳酸钙；NF/AC组——硝酸钾和氟化钠/精氨酸和碳酸钙；NA/AC组——硝酸钾和精氨酸/精氨酸和碳酸钙；GT/PN组——甘油和增稠剂/硝酸钾；NF/PN组——硝酸钾和氟化钠/硝酸钾；以及NA/PN组——硝酸钾和精氨酸/硝酸钾。使用数字模拟量表评估敏感度，并用分光光度计测量颜色变化（ΔE）。对获得 的敏感度值进行多变量方差分析（MANOVA），对颜色变化值进行随机方差分析（p<0.05）。
在整个临床疗程中，NF/AC组、NA/AC组、NF/PN组和NA/PN组与其他组相比呈现出较低的敏感度值且敏感度降低。在24周评估时，所有组均未表现出敏感度。从统计学角度来看，漂白开始四周后各组之间的颜色值未观察到显著差异（p = 0.074）。此外，在开始四周（p = 0.084）和24周（p = 0.118）后，所有组的颜色评估在统计学上相似。
我们的结果表明，在牙齿漂白方案中添加NF/S、NA/S、NF/AC和NA/AC脱敏剂可降低疼痛敏感度，而不影响其效果。
