Korea Food Research Institute, Wanju-gun, Korea.
Department of Life Science and Environmental Biochemistry, Pusan National University, Miryang, Korea.
J Med Food. 2020 Aug;23(8):870-878. doi: 10.1089/jmf.2020.4705. Epub 2020 Jun 30.
We sought to investigate the effect of extracts from petals (RPE) on skin whitening and anti-wrinkle activity. Tyrosinase activity was attenuated by RPE treatment, concomitant with the reduction of melanin accumulation in human B16F10 melanoma. Treatment of the facial skin of volunteers in a clinical trial with an RPE-containing formulation enhanced skin brightness (L* value) significantly. The underlying mechanism responsible was determined to be associated with mitogen-activated protein kinase (MAPK) activation. In addition, RPE exhibited anti-wrinkle formation activity of human dermal fibroblasts by suppressing matrix metalloproteinase (MMP)-1 level. study, RPE also inhibited solar ultraviolet-stimulated MMP-1 level by c-Jun regulation. Overall, our findings indicate that RPE evokes skin whitening and anti-wrinkle formation activity by regulating intracellular signaling, supporting its utility as an ingredient for skin whitening and anti-wrinkle cosmetic products.
我们旨在研究花瓣（RPE）提取物对皮肤美白和抗皱活性的影响。RPE 处理可减弱酪氨酸酶活性，同时减少人 B16F10 黑色素瘤中黑色素的积累。临床试验中用含有 RPE 的制剂处理志愿者的面部皮肤可显著提高皮肤亮度（L* 值）。确定其潜在机制与有丝分裂原激活的蛋白激酶（MAPK）的激活有关。此外，RPE 通过抑制基质金属蛋白酶（MMP）-1 水平表现出对人真皮成纤维细胞的抗皱形成活性。此外，RPE 通过 c-Jun 调节抑制太阳紫外线刺激的 MMP-1 水平。总体而言，我们的研究结果表明，RPE 通过调节细胞内信号来引发皮肤美白和抗皱形成活性，支持其作为皮肤美白和抗皱化妆品产品成分的应用。
