Cheng Fengrui, Feng Jinhong, Cao Ziling, Duan Qu, Li Haoying
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
J Cosmet Dermatol. 2025 Feb;24(2):e16710. doi: 10.1111/jocd.16710. Epub 2024 Dec 9.
Recently, numerous topical products containing plant-based ingredients have been reported to resist skin aging. However, there is a lack of sufficient evidence to substantiate these claims. This paper presents a comprehensive review and meta-analysis to evaluate the efficacy and safety of topical products containing plants or plant extracts in anti-aging.
Four databases-PubMed, Embase, Web of Science, and the Cochrane Library (CENTRAL)-were systematically searched for articles related to plant-based interventions and skin aging, covering the period from January 2000 to December 2024. A total of eight randomized controlled trials (RCTs) met the inclusion criteria and were included in the meta-analysis.
Products containing plant extracts demonstrated a statistically significant difference in improving skin hydration and skin elasticity, reducing melanin and erythema compared to other products. No significant statistical difference was observed in reducing transepidermal water loss (TEWL). Subgroup analysis revealed a significant statistical difference in improvement overall skin elasticity (R2) during short-term (≤ 8 weeks)treatments, while no statistical difference was observed during long-term (> 8 weeks)treatments. Additionally, no significant difference was observed in the specific measurements of skin elasticity, including R5 (net elasticity) and R7 (the ratio of elastic recovery to total deformation). Regarding safety, no adverse events were reported in six studies, while the remaining two studies did not specify whether adverse events occurred.
The meta-analysis results indicated that botanical preparations significantly enhanced skin hydration, reduced melanin levels and erythema, and increased overall skin elasticity. However, the analysis did not provide sufficient evidence to support a reduction in transepidermal water loss (TEWL), or improvements in R5 (net elasticity) and R7 (the ratio of elastic recovery to total deformation).
PROSPERO (york.ac.uk) identifier: CRD42023478803.
最近，有报道称许多含有植物成分的外用产品具有抗皮肤衰老的作用。然而，缺乏足够的证据来证实这些说法。本文进行了全面的综述和荟萃分析，以评估含有植物或植物提取物的外用产品在抗老化方面的疗效和安全性。
系统检索了四个数据库——PubMed、Embase、Web of Science和Cochrane图书馆（CENTRAL），以查找与植物性干预措施和皮肤衰老相关的文章，涵盖2000年1月至2024年12月期间。共有八项随机对照试验（RCT）符合纳入标准，并被纳入荟萃分析。
与其他产品相比，含有植物提取物的产品在改善皮肤水合作用和皮肤弹性、减少黑色素和红斑方面显示出统计学上的显著差异。在减少经表皮水分流失（TEWL）方面未观察到显著的统计学差异。亚组分析显示，在短期（≤8周）治疗期间，整体皮肤弹性（R2）改善存在显著统计学差异，而在长期（>8周）治疗期间未观察到统计学差异。此外，在皮肤弹性的具体测量指标，包括R5（净弹性）和R7（弹性恢复与总变形之比）方面未观察到显著差异。关于安全性，六项研究未报告不良事件，而其余两项研究未具体说明是否发生不良事件。
荟萃分析结果表明，植物制剂可显著增强皮肤水合作用、降低黑色素水平和红斑，并增加整体皮肤弹性。然而，该分析没有提供足够的证据支持经表皮水分流失（TEWL）的减少，或R5（净弹性）和R7（弹性恢复与总变形之比）的改善。
PROSPERO（york.ac.uk）标识符：CRD42023478803。
