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超声辅助提取花生壳中生物活性化合物的美白抗皱作用。

Skin-Whitening and Anti-Wrinkle Effects of Bioactive Compounds Isolated from Peanut Shell Using Ultrasound-Assisted Extraction.

机构信息

Department of Food Science, Sunmoon University, Natural Science 118, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si, Chungnam 336-708, Korea.

FlexPro Biotechnology, Natural Science 128, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si, Chungnam 336-708, Korea.

出版信息

Molecules. 2021 Feb 25;26(5):1231. doi: 10.3390/molecules26051231.

DOI:10.3390/molecules26051231
PMID:33669031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7956768/
Abstract

Response surface methodology was employed to optimize the ultrasound-assisted extraction (UAE) conditions for simultaneous optimization of dependent variables, including DPPH radical scavenging activity (RSA), tyrosinase activity inhibition (TAI), and collagenase activity inhibition (CAI) of peanut shell extracts. The effects of the main variables including extraction time (5.055.0 min, X), extraction temperature (26.094.0 °C, X), and ethanol concentration (0.0%99.5%, X) were optimized. Based on experimental values from each condition, quadratic regression models were derived for the prediction of optimum conditions. The coefficient of determination (R) of the independent variable was in the range of 0.890.96, which demonstrates that the regression model is suitable for the prediction. In predicting optimal UAE conditions based on the superimposing method, extraction time of 31.2 min, extraction temperature of 36.6 °C, and ethanol concentration of 93.2% were identified. Under these conditions, RSA of 74.9%, TAI of 50.6%, and CAI of 86.8% were predicted, showing good agreement with the experimental values. A reverse transcription polymerase chain reaction showed that peanut shell extract decreased mRNA levels of tyrosinase-related protein-1 and matrix metalloproteinase-3 genes in B16-F0 cell. Therefore, we identified the skin-whitening and anti-wrinkle effects of peanut shell extracts at protein as well as gene expression levels, and the results show that peanut shell is an effective cosmetic material for skin-whitening and anti-wrinkle effects. Based on this study, peanut shell, which was considered a byproduct, can be used for the development of healthy foods, medicines, and cosmetics.

摘要

响应面法被用于优化超声辅助提取 (UAE) 条件，以同时优化包括 DPPH 自由基清除活性 (RSA)、酪氨酸酶活性抑制 (TAI) 和胶原酶活性抑制 (CAI) 在内的多个依赖变量。主要变量（提取时间 (5.055.0 min, X)、提取温度 (26.094.0°C, X) 和乙醇浓度 (0.0%99.5%, X)）的影响被优化。基于每个条件下的实验值，导出了用于预测最佳条件的二次回归模型。独立变量的确定系数 (R) 在 0.890.96 范围内，表明回归模型适合预测。根据叠加法预测最佳 UAE 条件，提取时间为 31.2 min、提取温度为 36.6°C 和乙醇浓度为 93.2%。在这些条件下，预测 RSA 为 74.9%、TAI 为 50.6% 和 CAI 为 86.8%，与实验值吻合良好。逆转录聚合酶链反应显示，花生壳提取物降低了 B16-F0 细胞中酪氨酸酶相关蛋白-1 和基质金属蛋白酶-3 基因的 mRNA 水平。因此，我们在蛋白质和基因表达水平上确定了花生壳提取物的美白和抗皱作用，结果表明花生壳是一种有效的美白和抗皱化妆品材料。基于这项研究，被认为是副产品的花生壳可用于开发健康食品、药品和化妆品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a7/7956768/5e98ab28932c/molecules-26-01231-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a7/7956768/e22e5e455cb4/molecules-26-01231-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a7/7956768/865900dff6c7/molecules-26-01231-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a7/7956768/965be307e000/molecules-26-01231-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a7/7956768/3d22d4912071/molecules-26-01231-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a7/7956768/4c84775235b8/molecules-26-01231-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a7/7956768/5e98ab28932c/molecules-26-01231-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a7/7956768/e22e5e455cb4/molecules-26-01231-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a7/7956768/865900dff6c7/molecules-26-01231-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a7/7956768/965be307e000/molecules-26-01231-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a7/7956768/3d22d4912071/molecules-26-01231-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a7/7956768/4c84775235b8/molecules-26-01231-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a7/7956768/5e98ab28932c/molecules-26-01231-g006.jpg

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