Goor D A, Mohr R, Lavee J, Serraf A, Smolinsky A
Department of Thoracic and Cardiovascular Surgery, Chaim Sheba Medical Center, Tel Hashomer, Israel.
J Thorac Cardiovasc Surg. 1988 Aug;96(2):253-60.
Between 1980 and 1987, 40 patients with ischemic mitral insufficiency underwent mitral valve replacement (with a mechanical prosthesis) and coronary bypass grafting, 3.5 grafts per patient. The posterior mitral leaflet was preserved in 17 and resected in 23. Five arrived at operation in cardiogenic shock, 15 after recurrent episodes of pulmonary edema, and 20 electively, but in congestive heart failure. Twenty-five had unstable angina, and the remaining had chronic angina. Perioperative and early deaths occurred only in patients with an ejection fraction less than 35%. None of the 21 patients with an ejection fraction greater than 35% died, whereas eight of 19 with an ejection fraction less than 35% died, whereas eight of 19 with an ejection fraction less than 35% died (p less than 0.001). When causes of death in patients with an ejection fraction less than 35% were studied, operative and early mortality was zero of seven with preservation of the posterior mitral leaflet versus eight of 11 with excision of the leaflet (p = 0.035). We concluded that the high mortality in mitral valve replacement for ischemic mitral insufficiency is linked to an ejection fraction less than or equal to 35% and, in this particular group of patients, is due to the surgical destruction of the left ventricular chordae tendineae supportive apparatus. Preservation of this apparatus by preservation of the posterior mitral leaflet drastically reduces operative and early mortality. Preoperative cardiogenic shock, left ventricular aneurysmectomy, and multiple grafting (up to five grafts per patient) did not increase the risk of operation. Extensive revascularization (3.5 grafts per patient) provides improved long-term results.
1980年至1987年间,40例缺血性二尖瓣关闭不全患者接受了二尖瓣置换术(使用机械瓣膜)和冠状动脉搭桥术,每位患者平均搭桥3.5处。保留二尖瓣后叶的有17例,切除二尖瓣后叶的有23例。5例患者在心源性休克状态下接受手术,15例在反复出现肺水肿后接受手术,20例为择期手术,但均伴有充血性心力衰竭。25例有不稳定型心绞痛,其余患者有慢性心绞痛。围手术期死亡和早期死亡仅发生在射血分数低于35%的患者中。射血分数大于35%的21例患者无一死亡,而射血分数低于35%的19例患者中有8例死亡(p<0.001)。在研究射血分数低于35%的患者的死亡原因时,保留二尖瓣后叶的7例患者手术及早期死亡率为零,而切除二尖瓣后叶的11例患者中有8例死亡(p = 0.035)。我们得出结论,缺血性二尖瓣关闭不全患者二尖瓣置换术的高死亡率与射血分数小于或等于35%有关,在这一特定患者群体中,是由于左心室腱索支持装置的手术破坏所致。通过保留二尖瓣后叶来保留该装置可显著降低手术及早期死亡率。术前心源性休克、左心室室壁瘤切除术和多处搭桥(每位患者最多搭桥5处)并未增加手术风险。广泛的血管重建(每位患者平均搭桥3.5处)可改善长期疗效。