Département de Parasitologie-Mycologie-Médecine Tropicale, Faculté de Médecine, Université des Sciences de la Santé, BP 4009, Libreville, Gabon.
Gabonese Red Cross, BP 2274, Libreville, Gabon.
Trans R Soc Trop Med Hyg. 2020 Aug 1;114(8):618-626. doi: 10.1093/trstmh/traa047.
This cross-sectional study was carried out in different settlements of Gabon to determine the influence of single or multiple parasite carriage on haemoglobin (Hb) levels.
Between April 2015 and June 2016, healthy volunteers from urban, peri-urban and rural areas were screened for malaria, blood filariasis and intestinal parasitic infections using microscopic methods. Hb concentration was measured with a Hemocue analyser. The association between parasite carriage and anaemia was assessed.
Among the 775 volunteers examined, 319 (41.2%) were from rural villages and 76.0% were adults. Filariasis, intestinal parasitic infections, Plasmodium falciparum and polyparasitism were detected in 15.6, 14.6, 9.5 and 6.8% of participants, respectively. Anaemia prevalence was 72.6%, with rates of mild, moderate and severe anaemia being 30.9, 61.1 and 8.0%, respectively. The median Hb level was lowest in the presence of hookworms (7.1 g/dl [interquartile range {IQR} 6.8-7.5]), Schistosoma intercalatum (6.9 g/dl), Trichuris trichiura (10.1 g/dl [IQR 8.9-11.5]) and Plasmodium falciparum (10.0 g/dl [IQR 9.1-11.2]) compared with filariaemia (12.1 g/dl [IQR 10.5-13.2]) (p=0.03). Moderate to severe anaemia predominated among those single-infected with P. falciparum (69.5%) or co-infected with intestinal parasitic infections and P. falciparum (76.2%), while it was found in only 23.2% of individuals with filariasis. All participants with soil-transmitted helminths and more than half with a Blastocystis sp. (68.8%) infection had moderate anaemia.
The prevalence of anaemia is high. Asymptomatic parasite carriage is associated with anaemia in this surveyed population in Gabon.
本横断面研究在加蓬的不同定居点进行，旨在确定单一或多种寄生虫携带对血红蛋白（Hb）水平的影响。
2015 年 4 月至 2016 年 6 月，使用显微镜方法对来自城市、城乡结合部和农村地区的健康志愿者进行疟疾、血液丝虫病和肠道寄生虫感染筛查。使用 Hemocue 分析仪测量血红蛋白浓度。评估寄生虫携带与贫血之间的关联。
在 775 名被检查的志愿者中，319 名（41.2%）来自农村村庄，76.0%为成年人。丝虫病、肠道寄生虫感染、恶性疟原虫和多寄生虫感染分别在 15.6%、14.6%、9.5%和 6.8%的参与者中检出。贫血患病率为 72.6%，轻度、中度和重度贫血的发生率分别为 30.9%、61.1%和 8.0%。在钩虫（7.1 g/dl [四分位距 {IQR} 6.8-7.5]）、曼氏血吸虫（6.9 g/dl）、鞭虫（10.1 g/dl [IQR 8.9-11.5]）和恶性疟原虫（10.0 g/dl [IQR 9.1-11.2]）存在的情况下，中位血红蛋白水平最低与丝虫病（12.1 g/dl [IQR 10.5-13.2]）相比（p=0.03）。在单一感染恶性疟原虫（69.5%）或同时感染肠道寄生虫和恶性疟原虫（76.2%）的患者中，中度至重度贫血更为常见，而在感染丝虫病的患者中仅发现 23.2%。所有感染土壤传播性蠕虫的患者和超过一半感染蓝氏贾第鞭毛虫的患者（68.8%）均有中度贫血。
贫血的患病率很高。在加蓬的本次调查人群中，无症状寄生虫携带与贫血有关。
