Cappello Francesco, Gammazza Antonella Marino, Dieli Francesco, Macario Alberto Jl
Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo,90127 Palermo, Italy.
Euro-Mediterranean Institute of Science and Technology (IEMEST), 90141 Palermo, Italy.
J Clin Med. 2020 Jun 29;9(7):2038. doi: 10.3390/jcm9072038.
Viruses can generate molecular mimicry phenomena within their hosts. Why shouldsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) not be considered one of these?Information in this short review suggests that it might be so and, thus, encourages research aimingat testing this possibility. We propose, as a working hypothesis, that the virus induces antibodiesand that some of them crossreact with host's antigens, thus eliciting autoimmune phenomena withdevasting consequences in various tissues and organs. If confirmed, by in vitro and in vivo tests,this could drive researchers to find effective treatments against the virus.
病毒可在其宿主内产生分子模拟现象。为什么严重急性呼吸综合征冠状病毒2（SARS-CoV-2）不应被视为其中之一呢？这篇简短综述中的信息表明情况可能如此，因此鼓励开展旨在验证这一可能性的研究。作为一个可行的假设，我们提出该病毒诱导产生抗体，其中一些抗体与宿主抗原发生交叉反应，从而引发自身免疫现象，对各种组织和器官造成毁灭性后果。如果通过体外和体内试验得到证实，这可能促使研究人员找到针对该病毒的有效治疗方法。
