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阿斯利康新冠疫苗接种后继发T细胞缺陷的病例报告。

Case report of secondary T-cell deficiency following the AstraZeneca COVID-19 vaccine.

作者信息

Esmailian Amin, Barnes Sara Laura, Pumar Marsus

机构信息

Faculty of Medicine, Monash University, Melbourne, Australia.

Monash Lung Sleep Allergy and Immunology, Clayton, Australia.

出版信息

J Allergy Clin Immunol Glob. 2024 Sep 6;3(4):100339. doi: 10.1016/j.jacig.2024.100339. eCollection 2024 Nov.

DOI:10.1016/j.jacig.2024.100339
PMID:39380982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11459643/
Abstract

We present a case of secondary T-cell deficiency particularly affecting CD4 T cells, along with the emergence of chronic spontaneous urticaria in a patient following COVID-19 vaccination. The condition was partially managed with omalizumab after initial first-line therapy proved ineffective.

摘要

我们报告了一例继发于新型冠状病毒肺炎疫苗接种后出现慢性自发性荨麻疹的患者，其存在特别影响CD4 T细胞的继发性T细胞缺陷。在初始一线治疗无效后，使用奥马珠单抗对该病症进行了部分控制。

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本文引用的文献

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COVID-19 Vaccination in Autoimmune Diseases (COVAD) study: Vaccine safety in idiopathic inflammatory myopathies.COVID-19 疫苗接种在自身免疫性疾病（COVAD）研究中的应用：特发性炎性肌病的疫苗安全性。
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Inflammatory demyelinating polyneuropathy after the ChAdOx1 nCoV-19 vaccine may follow a chronic course.
腺病毒载体新冠疫苗（ChAdOx1 nCoV-19）接种后可能出现慢性炎症性脱髓鞘性多发神经病。
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Autoimmune rheumatic diseases: One or many diseases?自身免疫性风湿性疾病：一种还是多种疾病？
J Transl Autoimmun. 2021 Oct 28;4:100129. doi: 10.1016/j.jtauto.2021.100129. eCollection 2021.
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Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review.疫苗接种后 COVID-19 疫苗诱导的免疫性血栓性血小板减少症和脑静脉窦血栓形成：系统评价。
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Autoimmune hepatitis developing after the ChAdOx1 nCoV-19 (Oxford-AstraZeneca) vaccine.接种ChAdOx1 nCoV-19（牛津-阿斯利康）疫苗后发生的自身免疫性肝炎。
J Hepatol. 2021 Nov;75(5):1249-1250. doi: 10.1016/j.jhep.2021.06.014. Epub 2021 Jun 22.
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Lymphopenia, Lymphopenia-Induced Proliferation, and Autoimmunity.淋巴细胞减少症、淋巴细胞减少症诱导的增殖和自身免疫。
Int J Mol Sci. 2021 Apr 16;22(8):4152. doi: 10.3390/ijms22084152.
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Does SARS-CoV-2 Trigger Stress-InducedAutoimmunity by Molecular Mimicry? A Hypothesis.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是否通过分子模拟引发应激诱导的自身免疫？一种假说。
J Clin Med. 2020 Jun 29;9(7):2038. doi: 10.3390/jcm9072038.
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Autoimmune Theories of Chronic Spontaneous Urticaria.慢性自发性荨麻疹的自身免疫理论。
Front Immunol. 2019 Mar 29;10:627. doi: 10.3389/fimmu.2019.00627. eCollection 2019.