Palombo E, Porrino L J, Bankiewicz K S, Crane A M, Kopin I J, Sokoloff L
Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20892.
Brain Res. 1988 Jun 21;453(1-2):227-34. doi: 10.1016/0006-8993(88)90162-x.
The quantitative 2-[14C]deoxyglucose autoradiographic method was used to map the regional distribution of the acute effects of administration of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), on local cerebral glucose utilization in rhesus monkeys. Metabolic activity was increased (+80%) in the substantia nigra pars compacta, which has been shown to be the main target site of MPTP toxicity. Metabolic activity was also increased in the nucleus paranigralis, nucleus parabrachialis pigmentosus, and ventral lamella of the inferior olive. In contrast, substantial decreases in glucose utilization were found diffusely distributed throughout many of the other structures examined, most prominently in portions of the cerebral cortex, thalamus, and cerebellum.
采用定量2-[¹⁴C]脱氧葡萄糖放射自显影法，绘制神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）给药对恒河猴局部脑葡萄糖利用的急性效应的区域分布图。黑质致密部的代谢活性增加（+80%），该部位已被证明是MPTP毒性的主要靶位点。旁黑质核、臂旁色素核和下橄榄体腹侧薄片的代谢活性也增加。相比之下，在许多其他检查的结构中发现葡萄糖利用显著降低，最明显的是在大脑皮层、丘脑和小脑的部分区域。
