Graduate School of Biomedical Sciences, Nagasaki University.
Chem Pharm Bull (Tokyo). 2020;68(7):603-612. doi: 10.1248/cpb.c20-00008.
Cancer treatments have improved significantly during the last decade but are not yet satisfactory. Combination therapy is often administered to improve efficacy and safety. Drug delivery systems can also improve efficacy and safety. To control the spatiotemporal distribution of drugs, nanotechnology involving liposomes, solid lipid nanoparticles, and polymeric micelles has been developed. Co-delivery systems of multiple drugs are a promising approach to combat cancer. Synergistic effects and reduced side effects are expected from the use of co-delivery systems. In this review, we summarize various co-delivery systems for multiple drugs, including small-molecule drugs, nucleic acids, genes, and proteins. Co-delivery of drugs with different properties is relatively difficult, but some researchers have succeeded in developing such co-delivery systems. Environment-responsive carrier designs can control the release of cargos. Although their preparation is more complicated than that of mono-delivery systems, co-delivery systems can simplify clinical procedures and improve patient QOL.
在过去的十年中，癌症治疗有了显著的改善，但仍不尽如人意。联合治疗通常用于提高疗效和安全性。药物传递系统也可以提高疗效和安全性。为了控制药物的时空分布，已经开发了涉及脂质体、固体脂质纳米粒和聚合物胶束的纳米技术。多种药物的共递药系统是治疗癌症的一种很有前途的方法。共递药系统有望产生协同作用和减少副作用。在这篇综述中，我们总结了多种药物的共递药系统，包括小分子药物、核酸、基因和蛋白质。不同性质的药物共递药比较困难，但一些研究人员已经成功开发出这种共递药系统。环境响应载体设计可以控制货物的释放。虽然它们的制备比单递药系统复杂，但共递药系统可以简化临床程序并提高患者的生活质量。
