拉钩柯（Artocarpus lakoocha）嫩枝和树皮中的黄烷酮具有抗疟和抗结核活性。

Flavanones from the Twigs and Barks of Artocarpus lakoocha Having Antiplasmodial and Anti-TB Activities.

机构信息

Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University.

Department of Chemistry, Virginia Tech.

出版信息

Chem Pharm Bull (Tokyo). 2020;68(7):671-674. doi: 10.1248/cpb.c20-00080.

DOI:10.1248/cpb.c20-00080

PMID:32612002

Abstract

Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2-12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 with IC values of 36.7 and 33.9 µM, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC values of 15.0 and 57.1 µM. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 µM.

摘要

从粗榧枝叶的丙酮提取物中进行色谱分离，得到了一个新的黄烷酮化合物，即拉钩卡酮（1），以及 11 个已知化合物（2-12）。拉钩卡酮（1）和桑辛呋喃 B（5）对恶性疟原虫 Dd2 表现出较弱的抗疟原虫活性，IC 值分别为 36.7 和 57.1 μM。此外，桑辛呋喃 B（5）和桑辛呋喃 B（5）对 A2780 细胞系表现出细胞毒性，IC 值分别为 15.0 和 57.1 μM。此外，环古伦明（7）对结核分枝杆菌 H37Ra 显示出很强的抗分枝杆菌活性，最小抑菌浓度（MIC）值为 12.3 μM。