Ye Lei, Wei Ran, Huang Xin, Shi Wen-Qing, Yang Qi-Chen, Yuan Qing, Zhu Pei-Wen, Jiang Nan, Li Biao, Zhou Qiong, Zhou Fu-Qing, Shao Yi
Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Eye Center, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, Hubei Province, China.
Int J Ophthalmol. 2018 Jun 18;11(6):1056-1060. doi: 10.18240/ijo.2018.06.26. eCollection 2018.
This study investigated the changes in interhemispheric functional connectivity (FC) of the whole brain in open globe injury (OGI) patients, using voxel-mirrored homotopic connectivity (VMHC), and their relationships with clinical features. Totally, 16 male and 2 female acute OGI patients and 18 sex, age, and education-matched healthy volunteers were enrolled in the study. All subjects were scanned through functional magnetic resonance imaging (fMRI). Receiver operating characteristic (ROC) curves analyses had been used to identify the VMHC in these brain areas could be used as biomarkers to distinguish OGI and from healthy control (HC). The mean VMHC values in multiple brain areas and clinical OGI manifestations were evaluated with a Pearson correlation analysis. OGI patients had significantly decreased VMHC in the bilateral calcarine/lingual/cuneus (BA18, 19, 30) and middle occipital gyrus (BA18, 19). The OGI patients had abnormal interhemispheric FC in the dorsal visual pathway, which may represent the pathophysiological mechanism that underlies acute vision loss after OGI.
本研究采用体素镜像同伦连接性（VMHC），调查开放性眼球损伤（OGI）患者全脑半球间功能连接性（FC）的变化及其与临床特征的关系。本研究共纳入16例男性和2例女性急性OGI患者以及18名性别、年龄和教育程度匹配的健康志愿者。所有受试者均通过功能磁共振成像（fMRI）进行扫描。采用受试者工作特征（ROC）曲线分析来确定这些脑区的VMHC是否可作为区分OGI患者与健康对照（HC）的生物标志物。通过Pearson相关分析评估多个脑区的平均VMHC值与OGI临床症状之间的关系。OGI患者双侧距状/舌/楔叶（BA18、19、30）和枕中回（BA18、19）的VMHC显著降低。OGI患者在背侧视觉通路存在半球间FC异常，这可能代表了OGI后急性视力丧失的病理生理机制。
