注意缺陷多动障碍和/或自闭症谱系障碍患儿的镁状态
Magnesium Status in Children with Attention-Deficit/Hyperactivity Disorder and/or Autism Spectrum Disorder.
作者信息
Skalny Anatoly V, Mazaletskaya Anna L, Ajsuvakova Olga P, Bjørklund Geir, Skalnaya Margarita G, Chernova Lyubov N, Skalny Andrey A, Tinkov Alexey A
机构信息
Laboratory of Biotechnology and Applied Bioelementology, Yaroslavl State University, Yaroslavl, Russia.
Laboratory of Molecular Dietetics, IM Sechenov First Moscow State Medical University, Moscow, Russia.
出版信息
Soa Chongsonyon Chongsin Uihak. 2020 Jan 1;31(1):41-45. doi: 10.5765/jkacap.190036.
OBJECTIVE
The objective of this study was to assess serum, hair, and urinary magnesium (Mg) levels in children with attention-deficit/ hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and both ASD and ADHD to reveal potential interactive effects.
METHODS
A total of 148 boys aged 4-9 years old were enrolled in this study, including 44 children with ADHD, 40 pediatric patients with ASD, 32 patients with both ADHD and ASD, as well as 32 healthy neurotypical children. Hair, serum, and urinary Mg levels were assessed using inductively-coupled plasma mass spectrometry (ICP-MS). Laboratory quality control was performed using certified reference materials of human hair, plasma, and urine.
RESULTS
No significant group difference in serum Mg levels was observed. Mg content in hair was found to be reduced in children with ADHD and ADHD+ASD compared to that in healthy controls by 11% and 15%, respectively. Urinary Mg levels in children with ADHD+ASD exceeded the control, ADHD, and ASD values by 51, 76, and 65%, respectively. Factorial analysis revealed significant contribution of ADHD to hair and urinary Mg levels. Multiple regression analysis demonstrated that hair and urinary Mg levels were considered as significant predictors of neurodevelopmental disorder complexity.
CONCLUSION
We propose that impaired Mg status may provide a link between ADHD and ASD.
目的
本研究旨在评估患有注意力缺陷多动障碍（ADHD）、自闭症谱系障碍（ASD）以及同时患有ASD和ADHD的儿童的血清、头发和尿液中的镁（Mg）水平，以揭示潜在的交互作用。
方法
本研究共纳入148名4至9岁的男孩，包括44名ADHD儿童、40名ASD儿科患者、32名同时患有ADHD和ASD的患者以及32名健康的神经发育正常儿童。使用电感耦合等离子体质谱法（ICP-MS）评估头发、血清和尿液中的Mg水平。使用人发、血浆和尿液的标准参考物质进行实验室质量控制。
结果
未观察到血清Mg水平存在显著的组间差异。与健康对照组相比，ADHD儿童和ADHD + ASD儿童头发中的Mg含量分别降低了11%和15%。ADHD + ASD儿童的尿Mg水平分别比对照组、ADHD组和ASD组高出51%、76%和65%。因子分析显示ADHD对头发和尿Mg水平有显著影响。多元回归分析表明，头发和尿Mg水平被视为神经发育障碍复杂性的重要预测指标。
结论
我们认为Mg状态受损可能是ADHD和ASD之间的一个关联因素。
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