Xiong Jian-Wen, Zhan Jin-Qiong, Luo Tao, Chen Hai-Bo, Wan Qi-Gen, Wang Yan, Wei Bo, Yang Yuan-Jian
Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, China.
Biological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, China.
Front Neurosci. 2020 Jun 16;14:610. doi: 10.3389/fnins.2020.00610. eCollection 2020.
Cognitive impairments are a core feature of schizophrenia. Klotho is an anti-aging protein with demonstrated cognitive-enhancing effects on the brain. The purpose of this study was to investigate the differences in levels of plasma klotho between patients with schizophrenia and healthy controls, as well as the relationship between klotho level and cognitive function in patients. Forty patients with schizophrenia and 40 gender- and age-matched healthy individuals were recruited. Positive and Negative Syndrome Scale (PANSS) was used to assess the psychopathology of patients. A neuropsychological battery was performed to evaluate the cognitive function of participants. Plasma klotho was measured using enzyme-linked immunosorbent assay. We show that patients with schizophrenia performed worse in the neurocognitive tests than the healthy controls. The levels of plasma klotho were significantly higher in schizophrenia patients than in healthy controls ( < 0.001). In patients, plasma klotho levels were positively correlated with cognitive function with regard to attention ( = 0.010), working memory ( < 0.001), verbal memory ( = 0.044), executive function ( < 0.001), and composite cognitive score ( < 0.001). Stepwise linear regression analysis shows that executive function had the highest correlation with plasma klotho levels (β = 0.896, = 8.290, < 0.001). Collectively, these results indicate that anti-aging protein klotho may be implicated in the pathogenesis of schizophrenia, and increased klotho may act as a compensatory factor for the preservation of cognitive function in schizophrenia. Further studies are needed to investigate the dynamic changes of klotho and the mechanisms by which klotho modulates cognition in schizophrenia.
认知障碍是精神分裂症的核心特征。α-klotho是一种具有抗衰老作用的蛋白质，已证实其对大脑具有认知增强作用。本研究旨在探讨精神分裂症患者与健康对照者血浆α-klotho水平的差异，以及患者α-klotho水平与认知功能之间的关系。招募了40例精神分裂症患者和40例年龄及性别匹配的健康个体。采用阳性与阴性症状量表（PANSS）评估患者的精神病理学。进行了一套神经心理学测试以评估参与者的认知功能。采用酶联免疫吸附测定法测量血浆α-klotho。我们发现，精神分裂症患者在神经认知测试中的表现比健康对照者差。精神分裂症患者的血浆α-klotho水平显著高于健康对照者（<0.001）。在患者中，血浆α-klotho水平与注意力（=0.010）、工作记忆（<0.001）、言语记忆（=0.044）、执行功能（<0.001）和综合认知评分（<0.001）方面的认知功能呈正相关。逐步线性回归分析表明，执行功能与血浆α-klotho水平的相关性最高（β=0.896, =8.290, <0.001）。总体而言，这些结果表明，抗衰老蛋白α-klotho可能与精神分裂症的发病机制有关，α-klotho水平升高可能作为一种补偿因素来维持精神分裂症患者的认知功能。需要进一步研究来探讨α-klotho的动态变化以及α-klotho调节精神分裂症认知的机制。
