Birdi Amandeep, Tomo Sojit, Sharma Monika, Yadav Pankaj, Charan Jaykaran, Sharma Praveen, Yadav Dharmveer
Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India.
Department of Bioscience and Bioengineering, IIT Jodhpur, Jodhpur, India.
Indian J Clin Biochem. 2024 Jul;39(3):429-437. doi: 10.1007/s12291-023-01132-5. Epub 2023 Mar 31.
Neuropsychiatric disorders are mainly concerned with the behavioural, emotional and cognition symptoms that may be due to disturbed cerebral functions or extracerebral disease. Klotho protein is an antiaging protein that is mostly associated with cognitive changes in these disorders and thus this meta-analysis is conducted in order to find Klotho proteins association with these disorders. We searched related topics in pubmed, by using the key word i.e. Klotho and related disorder from neuropsychiatry e.g. Klotho levels and schizophrenia, Klotho levels and parkinsonism etc. Total 82 studies were found till 9th February 2021 after extensive search and 10 studies were selected for further analysis. The meta-analysis of studies was performed using the Random effect model. The forest plot represented each study in the meta-analysis, so as to make the comparison of SMD value across studies. The meta-analysis outcome demonstrated that overall schizophrenia had higher klotho levels as compared with bipolar disorder, psychosocial stress, parkinsonism, multiple sclerosis, depression, Alzheimer's disease, and healthy controls, followed by MS. The meta-analysis also found that bipolar disorder and Alzheimer's disease were associated with low klotho levels as compared to schizophrenia. The results indicate a significant association of the klotho levels and schizophrenia. Further studies are needed to characterize the potential biological roles of klotho levels in psychiatric disorders.
神经精神疾病主要涉及可能由大脑功能紊乱或脑外疾病引起的行为、情绪和认知症状。klotho蛋白是一种抗衰老蛋白，主要与这些疾病中的认知变化相关，因此进行这项荟萃分析是为了找出klotho蛋白与这些疾病的关联。我们在PubMed中搜索相关主题，使用的关键词是“Klotho”以及神经精神病学中的相关疾病，如“Klotho水平与精神分裂症”“Klotho水平与帕金森症”等。经过广泛搜索，截至2021年2月9日共找到82项研究，从中选取10项研究进行进一步分析。采用随机效应模型对这些研究进行荟萃分析。森林图展示了荟萃分析中的每项研究，以便对各研究间的标准化均值差（SMD）值进行比较。荟萃分析结果表明，总体而言，与双相情感障碍、心理社会压力、帕金森症、多发性硬化症、抑郁症、阿尔茨海默病及健康对照相比，精神分裂症患者的klotho水平更高，其次是多发性硬化症。荟萃分析还发现，与精神分裂症相比，双相情感障碍和阿尔茨海默病患者的klotho水平较低。结果表明klotho水平与精神分裂症之间存在显著关联。需要进一步研究来明确klotho水平在精神疾病中的潜在生物学作用。
