Rager-Zisman B
Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negey, Beer Sheva, Israel.
Isr J Med Sci. 1988 Jul;24(7):363-5.
The studies summarized here indicate that viruses can serve as a trigger factor of autoimmune reactivity in various ways. The low frequency of autoimmune diseases in the population, the familial nature and the HLA associations of these diseases suggest that a multifactorial control is conditional to the virus infections. It is also evident that the presence of high levels of autoantibodies in itself is insufficient to induce significant "self"-reactivity. Autoimmunity associated with clinical manifestations will occur only if the autoantibody or autoreactive cells will be directed against a component that participates in the disease production. In spite of the large body of evidence that has been accumulated in the past decade, the relationship between autoimmunity and specific virus infection is still obscure. Hopefully, the next decade will provide new insight into the relevance of viruses in the pathogenesis of autoimmune diseases.
此处总结的研究表明，病毒可以通过多种方式作为自身免疫反应的触发因素。人群中自身免疫性疾病的低发病率、这些疾病的家族性特征以及与HLA的关联表明，多因素控制对于病毒感染是有条件的。同样明显的是，高水平自身抗体的存在本身不足以诱导显著的“自身”反应性。只有当自身抗体或自身反应性细胞针对参与疾病产生的成分时，才会发生与临床表现相关的自身免疫。尽管在过去十年中积累了大量证据，但自身免疫与特定病毒感染之间的关系仍然不明朗。有望在未来十年对病毒在自身免疫性疾病发病机制中的相关性提供新的见解。
