在具有 突变的高级别浆液性卵巢癌中，未经预先化疗的情况下对帕博利珠单抗持续应答。
Sustained response to pembrolizumab without prior chemotherapy in high-grade serous ovarian carcinoma with mutation.
作者信息
Terzic Julie, Seipel Amanda, Dubuisson Jean, Tille Jean-Christophe, Tsantoulis Petros, Addeo Alfredo, Labidi-Galy S Intidhar
机构信息
Department of Oncology, Hôpitaux Universitaires de Genève, Genève, Switzerland.
Department of Diagnosis, Division of Clinical Pathology, Hôpitaux Universitaires de Genève, Genève, Switzerland.
出版信息
Gynecol Oncol Rep. 2020 Jun 15;33:100600. doi: 10.1016/j.gore.2020.100600. eCollection 2020 Aug.
Abstract
•Metastatic mutated HGSOC showed objective and sustained response to pembrolizumab.•The tumor was massively infiltrated by CD8 T cells while PD-L1 TPS was at 10%.• mutated HGSOC showed up-regulation of and
摘要
•转移性突变高级别浆液性卵巢癌对帕博利珠单抗显示出客观且持续的反应。
•肿瘤被CD8 T细胞大量浸润，而程序性死亡配体1（PD-L1）肿瘤比例评分（TPS）为10%。
•突变的高级别浆液性卵巢癌显示出……的上调 以及
Zotero 插件