University of Michigan College of Pharmacy, Ann Arbor, MI, USA.
VA Ann Arbor Healthcare System, MI, USA.
J Pharm Pract. 2021 Oct;34(5):786-793. doi: 10.1177/0897190020934289. Epub 2020 Jul 2.
Cannabinoid hyperemesis syndrome is a condition characterized by cyclic severe nausea, vomiting, and abdominal pain associated with frequent, long-term marijuana use. The condition resolves with cessation of cannabis but may be temporarily relieved by bathing in hot water. Topical capsaicin cream may also alleviate symptoms, perhaps through antiemetic effects produced by activation of TRPV1 receptors, similar to that of hot water bathing. This review summarizes the epidemiology, clinical presentation, diagnosis, pathophysiology, and management of cannabinoid hyperemesis syndrome, focusing on treatment with topical capsaicin.
大麻相关性呕吐综合征是一种以周期性严重恶心、呕吐和腹痛为特征的病症，与长期、频繁使用大麻有关。该病症在停止使用大麻后可缓解，但热水浴可能暂时缓解症状。辣椒素乳膏也可能通过激活 TRPV1 受体产生止吐作用来缓解症状，其作用类似于热水浴。本综述总结了大麻相关性呕吐综合征的流行病学、临床表现、诊断、病理生理学和管理，重点介绍了辣椒素乳膏的治疗作用。
