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不同细胞遗传学分组的急性髓系白血病中 HOX 基因和膜蛋白的表达和调控。

The expression and regulation of HOX genes and membrane proteins among different cytogenetic groups of acute myeloid leukemia.

机构信息

Department of Environmental Engineering, Wenhua College, Wuhan, China.

Hubei Bioinformatics & Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.

出版信息

Mol Genet Genomic Med. 2020 Sep;8(9):e1365. doi: 10.1002/mgg3.1365. Epub 2020 Jul 2.

DOI:10.1002/mgg3.1365
PMID:32614525
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7507697/
Abstract

BACKGROUND

The cytogenetic aberrations were considered as markers for diagnosis and prognosis in acute myeloid leukemia (AML), while the expression and regulation under different cytogenetic groups remain to be fully elucidated.

METHODS

In this paper, for favorable, poor, and cytogenetically normal groups of AML patients, we performed comprehensive bioinformatics analyses including identifying differentially expressed genes (DEGs) and microRNAs (miRNAs) among them, functional enrichment and regulatory networks.

RESULTS

We found that DEGs were enriched in membrane-related processes. Eleven genes and two miRNAs were significantly differentially expressed among these three AML groups. In survival analysis, membrane-related genes and several miRNAs were significant on prognostic outcome. Notably, six HOXA and three HOXB genes were significantly in low expression and high methylation in AML with favorable cytogenetics. Meanwhile, the miRNA-HOX gene co-regulatory networks revealed that HOXA5 was a hub node and regulated an AML oncogene SPARC.

CONCLUSION

Our work may provide novel insights to the molecular characteristics and classification between AML with different cytogenetics.

摘要

背景

细胞遗传学异常被认为是急性髓细胞白血病（AML）诊断和预后的标志物，而不同细胞遗传学组中的表达和调控仍有待充分阐明。

方法

在这项研究中，我们对 AML 患者的良好、不良和细胞遗传学正常组进行了全面的生物信息学分析，包括识别其中的差异表达基因（DEGs）和 microRNAs（miRNAs）、功能富集和调控网络。

结果

我们发现 DEGs 富集在与膜相关的过程中。在这三组 AML 中，有 11 个基因和 2 个 miRNA 显著差异表达。在生存分析中，与膜相关的基因和一些 miRNA 对预后结果有显著影响。值得注意的是，在具有良好细胞遗传学的 AML 中，六个 HOXA 和三个 HOXB 基因的表达水平较低且甲基化程度较高。同时，miRNA-HOX 基因共调控网络表明 HOXA5 是一个枢纽节点，并调控 AML 癌基因 SPARC。

结论

我们的工作可能为不同细胞遗传学 AML 的分子特征和分类提供新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/4ffba2cff696/MGG3-8-e1365-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/8c68c73c6b48/MGG3-8-e1365-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/c62cfeb0c6ff/MGG3-8-e1365-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/ecf29518191d/MGG3-8-e1365-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/4384125d6183/MGG3-8-e1365-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/f9727e29bd66/MGG3-8-e1365-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/2853d93a2f9a/MGG3-8-e1365-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/4ffba2cff696/MGG3-8-e1365-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/8c68c73c6b48/MGG3-8-e1365-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/c62cfeb0c6ff/MGG3-8-e1365-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/ecf29518191d/MGG3-8-e1365-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/4384125d6183/MGG3-8-e1365-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/f9727e29bd66/MGG3-8-e1365-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/2853d93a2f9a/MGG3-8-e1365-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74f4/7507697/4ffba2cff696/MGG3-8-e1365-g007.jpg

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