AnimalTFDB 3.0：一个全面的动物转录因子注释和预测资源。
AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors.
机构信息
Department of Bioinformatics and Systems Biology, Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Huazhong University of Science and Technology Ezhou Industrial Technology Research Institute, Ezhou, Hubei 436044, PR China.
出版信息
Nucleic Acids Res. 2019 Jan 8;47(D1):D33-D38. doi: 10.1093/nar/gky822.
The Animal Transcription Factor DataBase (AnimalTFDB) is a resource aimed to provide the most comprehensive and accurate information for animal transcription factors (TFs) and cofactors. The AnimalTFDB has been maintained and updated for seven years and we will continue to improve it. Recently, we updated the AnimalTFDB to version 3.0 (http://bioinfo.life.hust.edu.cn/AnimalTFDB/) with more data and functions to improve it. AnimalTFDB contains 125,135 TF genes and 80,060 transcription cofactor genes from 97 animal genomes. Besides the expansion in data quantity, some new features and functions have been added. These new features are: (i) more accurate TF family assignment rules; (ii) classification of transcription cofactors; (iii) TF binding sites information; (iv) the GWAS phenotype related information of human TFs; (v) TF expressions in 22 animal species; (vi) a TF binding site prediction tool to identify potential binding TFs for nucleotide sequences; (vii) a separate human TF database web interface (HumanTFDB) was designed for better utilizing the human TFs. The new version of AnimalTFDB provides a comprehensive annotation and classification of TFs and cofactors, and will be a useful resource for studies of TF and transcription regulation.
动物转录因子数据库（AnimalTFDB）是一个旨在为动物转录因子（TFs）及其共因子提供最全面、最准确信息的资源。AnimalTFDB 已经维护和更新了七年，我们将继续改进它。最近，我们将 AnimalTFDB 更新到了 3.0 版本（http://bioinfo.life.hust.edu.cn/AnimalTFDB/），增加了更多的数据和功能来改进它。AnimalTFDB 包含了 125135 个 TF 基因和 80060 个转录共因子基因，来自 97 种动物基因组。除了数据量的增加，还增加了一些新的功能。这些新功能包括：（i）更准确的 TF 家族分配规则；（ii）转录共因子的分类；（iii）TF 结合位点信息；（iv）人类 TF 的 GWAS 表型相关信息；（v）22 种动物物种中的 TF 表达；（vi）一个 TF 结合位点预测工具，用于识别核苷酸序列的潜在结合 TF；（vii）为了更好地利用人类 TF，设计了一个单独的人类 TF 数据库网络界面（HumanTFDB）。新版本的 AnimalTFDB 提供了 TF 和共因子的全面注释和分类，将成为 TF 和转录调控研究的有用资源。
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