Department of Health Behavior and Policy, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Office of Health Equity and Disparities Research, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.
Cancer. 2020 Sep 1;126(17):4059-4066. doi: 10.1002/cncr.33054. Epub 2020 Jul 2.
Physical activity (PA) is recommended for women with breast cancer (BC); however, data are sparse on the association of PA with quality of life (QOL) and patient-reported symptoms for women on adjuvant endocrine therapy (AET).
Women with hormone receptor-positive BC who were taking AET completed standardized surveys about their health-related QOL, AET-related symptoms, and levels of PA using validated measures. A Wald chi-square test and an analysis of variance were used to assess associations with PA and independent variables. Generalized linear regression analyses assessed associations between PA, QOL, and AET-related symptoms.
The analytic cohort included 485 Black and White women. Black race, a high body mass index (BMI), and being on aromatase inhibitors (vs tamoxifen) were associated with lower PA in a bivariate analysis. In a multivariate analysis, lower self-reported PA was associated with a high BMI (P = .02) and chemotherapy uptake (P = .006). Better health-related QOL (P = .01), less severe overall AET-related symptoms (P = .02), and less severe gynecological symptoms (P = .03) were associated with increasing levels of moderate PA.
Among women taking AET, moderate levels of PA may be associated with fewer medication-related symptoms and overall better ratings of health-related QOL. Because of the low levels of PA observed in the sample overall and particularly for Black women, identifying successful strategies to promote PA are needed.
体力活动（PA）被推荐用于患有乳腺癌（BC）的女性；然而，关于 PA 与接受辅助内分泌治疗（AET）的女性的生活质量（QOL）和患者报告的症状之间的关联的数据很少。
正在服用 AET 的激素受体阳性 BC 女性使用经过验证的措施，完成了关于其与健康相关的 QOL、AET 相关症状和 PA 水平的标准化调查。使用 Wald 卡方检验和方差分析评估与 PA 和自变量的关联。广义线性回归分析评估了 PA、QOL 和 AET 相关症状之间的关联。
分析队列包括 485 名黑人和白人女性。在单变量分析中，黑种人、高体重指数（BMI）和使用芳香酶抑制剂（与他莫昔芬相比）与较低的 PA 相关。在多变量分析中，较低的自我报告的 PA 与较高的 BMI（P =.02）和化疗使用率（P =.006）相关。更好的健康相关 QOL（P =.01）、更轻微的总体 AET 相关症状（P =.02）和更轻微的妇科症状（P =.03）与中度 PA 水平的增加相关。
在接受 AET 的女性中，适度的 PA 水平可能与较少的药物相关症状和总体更好的健康相关 QOL 评分相关。由于整个样本中观察到的 PA 水平较低，尤其是黑人女性，因此需要确定成功的促进 PA 的策略。
