稳定型冠状动脉疾病患者芬兰式桑拿浴的急性血管获益。

Acute Vascular Benefits of Finnish Sauna Bathing in Patients With Stable Coronary Artery Disease.

机构信息

Cardiovascular Prevention and Rehabilitation Centre, Montréal Heart Institute, Montréal, Québec, Canada; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.

Research Centre, Montréal Heart Institute, Montréal, Québec, Canada.

出版信息

Can J Cardiol. 2021 Mar;37(3):493-499. doi: 10.1016/j.cjca.2020.06.017. Epub 2020 Jun 29.

DOI:10.1016/j.cjca.2020.06.017

PMID:32615263

Abstract

BACKGROUND

Finnish sauna bathing habits are associated with a decreased risk of cardiovascular mortality. The physiologic adaptations mediating this association remain to be fully elucidated. This study tested the hypothesis that Finnish sauna bathing acutely improves peripheral flow-mediated dilation (FMD) in middle-aged and older adults with stable coronary artery disease (CAD).

METHODS

Twenty-two adults (20 male, 2 female; 67 ± 10 years) with stable CAD underwent 2 periods of 10 minutes in a Finnish sauna (81.3 ± 2.7°C, 23 ± 3% humidity) separated by 10 minutes of thermoneutral rest. Before and 51 ± 8 minutes after sauna bathing, brachial artery FMD and postocclusive reactive hyperemia (PORH) were evaluated by means of Doppler ultrasound.

RESULTS

Sauna bathing increased core temperature (mean +0.66°C [95% CI 0.54-0.77], P < 0.01) and heart rate (+27 beats/min [24-29], P < 0.01), and decreased systolic (-19 mm Hg [-31 to -6]; P < 0.01) and diastolic (-6 mm Hg [-11 to -1], P < 0.01) blood pressures. Brachial artery FMD was greater after sauna bathing (+1.21% [0.16-2.26], P = 0.04), whereas PORH was unchanged (peak: +0.51 mL/min/mm Hg [-0.13 to 1.15], P = 0.11; area under the curve: +0.21 mL/mm Hg [-0.12 to 0.54]; P = 0.19).

CONCLUSIONS

A typical Finnish sauna bathing session acutely improves peripheral FMD in middle-aged and older adults with stable CAD.

摘要

背景

芬兰式桑拿浴习惯与心血管死亡率降低有关。介导这种关联的生理适应仍有待充分阐明。本研究检验了以下假设，即在中年和老年稳定型冠状动脉疾病（CAD）患者中，芬兰式桑拿浴可急性改善外周血流介导的扩张（FMD）。

方法

22 名成年人（20 名男性，2 名女性；67±10 岁）患有稳定型 CAD，他们在芬兰桑拿浴（81.3±2.7°C，23±3%湿度）中进行 2 次 10 分钟的浴疗，每次浴疗之间休息 10 分钟。在桑拿浴前和桑拿浴后 51±8 分钟，通过多普勒超声评估肱动脉 FMD 和闭塞后反应性充血（PORH）。

结果

桑拿浴使核心体温升高（平均升高 0.66°C[95%置信区间 0.54-0.77]，P<0.01）和心率增加（增加 27 次/分钟[24-29]，P<0.01），并降低收缩压（降低 19mmHg[-31 至-6]，P<0.01）和舒张压（降低 6mmHg[-11 至-1]，P<0.01）。桑拿浴后肱动脉 FMD 更高（增加 1.21%[0.16-2.26]，P=0.04），而 PORH 无变化（峰值：增加 0.51mL/min/mm Hg[-0.13 至 1.15]，P=0.11；曲线下面积：增加 0.21mL/mm Hg[-0.12 至 0.54]；P=0.19）。