Bellini David, Lloyd Alex, Havenith George, Leicht Christof A, Bailey Stephen J, Maley Matthew J
Environmental Ergonomics Research Centre, Loughborough University, Loughborough, UK.
School of Sport, Exercise, and Health Sciences, Loughborough University, Loughborough, UK.
Temperature (Austin). 2025 Jan 24;12(2):149-165. doi: 10.1080/23328940.2025.2453959. eCollection 2025.
Cardiovascular disease is more prevalent in individuals of Black-African (BA) and South-Asian (SA) descent than White-European (WE) counterparts, with vascular dysfunction identified as contributing to this disparity. Chronic heat therapy can elicit positive vascular adaptations, potentially underpinned by the repeated cardiovascular strain experienced during acute heat exposures. This study examined the cutaneous peripheral microvascular responses following acute hot (HWI) and thermoneutral (CON) water immersion between males of WE, BA, and SA descent. Thirty-one young, healthy WE ( = 10), BA ( = 10), SA ( = 11) males completed 60 minutes of HWI (39°C) and CON (36°C) with thermoregulatory, cardiovascular, and perceptual responses measured throughout. Following 60 minutes of thermoneutral rest, forearm and Great toe cutaneous vascular conductance (CVC) were recorded during cutaneous post-occlusive reactive hyperemia (PORH) and local heating (LH). Baseline CVC was similar between groups ( ≥ 0.08). During PORH, BA had lower peak forearm and Great toe CVC than WE and SA, and a reduced CVC area under the curve compared to WE ( ≤ 0.01). Furthermore, BA Great toe CVC was blunted compared to WE and SA during both 42°C ( ≤ 0.033) and 44°C ( ≤ 0.02) LH, respectively. Great toe CVC was acutely increased following HWI in responses to 44°C LH compared to CON ( ≤ 0.039), with no race × condition interaction effects. In conclusion, despite blunted microvascular responses in BA, acute HWI did not elicit distinct effects between males of WE, BA, and SA descent, although microvascular responses to LH were greater following HWI.
心血管疾病在非洲裔黑人（BA）和南亚裔（SA）个体中比欧洲裔白人（WE）更为普遍，血管功能障碍被认为是导致这种差异的原因。慢性热疗可以引发积极的血管适应性变化，这可能是由急性热暴露期间反复经历的心血管应激所支撑。本研究调查了WE、BA和SA裔男性在急性热水浸泡（HWI）和热中性（CON）水浸泡后的皮肤外周微血管反应。31名年轻、健康的WE（n = 10）、BA（n = 10）、SA（n = 11）男性完成了60分钟的HWI（39°C）和CON（36°C），并在整个过程中测量了体温调节、心血管和感知反应。在60分钟的热中性休息后，在皮肤闭塞后反应性充血（PORH）和局部加热（LH）期间记录前臂和大脚趾皮肤血管传导率（CVC）。各组之间的基线CVC相似（≥0.08）。在PORH期间，BA的前臂和大脚趾CVC峰值低于WE和SA，与WE相比，曲线下CVC面积减小（≤0.01）。此外，在42°C（≤0.033）和44°C（≤0.02）LH期间，BA的大脚趾CVC分别比WE和SA迟钝。与CON相比，HWI后大脚趾CVC在对44°C LH的反应中急性增加（≤0.039），没有种族×条件交互作用效应。总之，尽管BA的微血管反应迟钝，但急性HWI在WE、BA和SA裔男性之间并未引发明显差异，尽管HWI后对LH的微血管反应更大。
