Gravel Hugo, Coombs Geoff B, Behzadi Parya, Marcoux-Clément Virginie, Barry Hadiatou, Juneau Martin, Nigam Anil, Gagnon Daniel
Cardiovascular Prevention and Rehabilitation Centre, Montreal Heart Institute, Montréal, Canada.
Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Canada.
Physiol Rep. 2019 Jul;7(13):e14166. doi: 10.14814/phy2.14166.
Regular Finnish sauna bathing is associated with a reduced risk of all-cause and cardiovascular mortality in middle-aged and older adults. Potential acute physiological adaptations induced by sauna bathing that underlie this relationship remain to be fully elucidated. The purpose of this study was to determine if typical Finnish sauna sessions acutely improve brachial artery flow-mediated dilation (FMD) and reactive hyperemia (RH) in healthy middle-aged and older adults. Using a randomized crossover design, FMD and RH were evaluated in 21 healthy adults (66 ± 6 years, 10 men/11 women) before and after each of the following conditions: (1) 1 × 10 min of Finnish sauna bathing (80.2 ± 3.2°C, 23 ± 2% humidity); (2) 2 × 10 min of sauna bathing separated by 10 min of rest outside the sauna; (3) a time control period (10 min of seated rest outside the sauna). FMD was taken as the peak change from baseline in brachial artery diameter following 5 min of forearm ischemia, whereas RH was quantified as both peak and area-under-the-curve forearm vascular conductance postischemia. FMD was statistically similar pre to post 1 × 10 min (4.69 ± 2.46 to 5.41 ± 2.64%, P = 0.20) and 2 × 10 min of sauna bathing (4.16 ± 1.79 to 4.55 ± 2.14%, P = 0.58). Peak and area-under-the-curve forearm vascular conductance were also similar following both sauna interventions. These results suggest that typical Finnish sauna bathing sessions do not acutely improve brachial artery FMD and RH in healthy middle-aged and older adults.
在中年及老年人群中，经常进行芬兰式桑拿浴与全因死亡率和心血管疾病死亡率降低相关。桑拿浴所引发的潜在急性生理适应性变化是这种关系的基础，但其仍有待充分阐明。本研究的目的是确定典型的芬兰式桑拿浴疗程是否能在健康的中年及老年人中急性改善肱动脉血流介导的血管舒张（FMD）和反应性充血（RH）。采用随机交叉设计，在以下每种情况前后，对21名健康成年人（66±6岁，10名男性/11名女性）的FMD和RH进行评估：（1）1次10分钟的芬兰式桑拿浴（80.2±3.2°C，湿度23±2%）；（2）2次10分钟的桑拿浴，中间间隔10分钟在桑拿室外休息；（3）一个时间对照组（在桑拿室外静坐休息10分钟）。FMD取前臂缺血5分钟后肱动脉直径相对于基线的峰值变化，而RH则量化为缺血后前臂血管传导性的峰值和曲线下面积。1次10分钟（4.69±2.46至5.41±2.64%，P = 0.20）和2次10分钟的桑拿浴后（4.16±1.79至4.55±2.14%，P = 0.58），FMD在统计学上无显著差异。两种桑拿干预后，前臂血管传导性的峰值和曲线下面积也相似。这些结果表明，典型的芬兰式桑拿浴疗程并不能在健康的中年及老年人中急性改善肱动脉FMD和RH。
