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衰老相关的肌少症性肥胖:心血管结局和死亡率。

Sarcopenic obesity in ageing: cardiovascular outcomes and mortality.

机构信息

Epidemiology and Public Health Group, University of Exeter Medical School, ExeterEX1 2LU, UK.

Department of Primary Care and Population Health, Royal Free Campus, University College London, LondonNW3 2PF, UK.

出版信息

Br J Nutr. 2020 Nov 28;124(10):1102-1113. doi: 10.1017/S0007114520002172. Epub 2020 Jun 18.

Abstract

Obesity is a major public health issue with prevalence increasing worldwide. Obesity is a well-established risk factor for CVD and mortality in adult populations. However, the impact of being overweight or obese in the elderly on CVD and mortality is controversial. Some studies even suggest that overweight and obesity, measured by BMI, are apparently associated with a decreased mortality risk (known as the obesity paradox). Ageing is associated with an increase in visceral fat and a progressive loss of muscle mass. Fat mass is positively associated and lean mass is negatively associated with risk of mortality. Therefore, in older adults BMI is not a good indicator of obesity. Sarcopenia has been defined as the degenerative loss of muscle mass, quality and strength with age and is of major concern in ageing populations. Sarcopenia has previously been associated with increased risks of metabolic impairment, cardiovascular risk factors, physical disability and mortality. It is possible for sarcopenia to co-exist with obesity, and sarcopenic obesity is a new class of obesity in older adults who have high adiposity levels together with low muscle mass, quality or strength. Therefore, sarcopenia with obesity may act together to increase their effect on metabolic disorders, CVD and mortality. This review will discuss the available evidence for the health implications of sarcopenic obesity on CVD and mortality in older adults.

摘要

肥胖是一个全球性的主要公共卫生问题,其患病率正在不断增加。肥胖是成年人心血管疾病和死亡率的一个既定风险因素。然而,超重或肥胖对老年人心血管疾病和死亡率的影响存在争议。一些研究甚至表明,体重指数(BMI)衡量的超重和肥胖与降低死亡率风险明显相关(即肥胖悖论)。随着年龄的增长,内脏脂肪会增加,肌肉量会逐渐减少。脂肪量与死亡率的风险呈正相关,而瘦体重与死亡率的风险呈负相关。因此,在老年人中,BMI 不是肥胖的良好指标。肌少症被定义为随着年龄的增长肌肉质量、质量和力量的进行性丧失,在老龄化人群中是一个主要关注点。肌少症以前与代谢损伤、心血管风险因素、身体残疾和死亡率的风险增加有关。肌少症与肥胖并存是可能的,肌少症性肥胖是一种新的肥胖类型,存在于脂肪水平高但肌肉质量、质量或力量低的老年人群中。因此,肥胖合并肌少症可能会共同增加其对代谢紊乱、心血管疾病和死亡率的影响。这篇综述将讨论有关肌少症性肥胖对老年人心血管疾病和死亡率的健康影响的现有证据。

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