携带基因 rs10830963 常见变异的 2 型糖尿病患者心肌梗死风险增加。
Increased Risk of Myocardial Infarction Among Patients With Type 2 Diabetes Who Carry the Common rs10830963 Variant in the Gene.
机构信息
Department of Neuroscience, Uppsala University, Uppsala, Sweden
Department of Neuroscience, Uppsala University, Uppsala, Sweden.
出版信息
Diabetes Care. 2020 Sep;43(9):2289-2292. doi: 10.2337/dc20-0507. Epub 2020 Jul 2.
Abstract
OBJECTIVE
The common single nucleotide polymorphism rs10830963 associates with risk of type 2 diabetes (T2D). Here, we examine the association between this gene variant and the risk of myocardial infarction (MCI) among patients with T2D. MCI is a main cause of death and disability among such individuals.
RESEARCH DESIGN AND METHODS
Data from the UK Biobank cohort were used in order to examine the association between rs10830963 and incidence of MCI (fatal and nonfatal) among 13,655 participants with probable T2D during a follow-up period of 6.8 years.
RESULTS
Assuming an additive genetic model, a positive association was found between the rs10830963 variant in the gene and the risk for incident MCI during the 6.8-year follow-up (adjusted hazard ratio per G allele 1.19 [95% CI 1.02, 1.40], = 0.03).
CONCLUSIONS
The rs10830963 polymorphism may be a useful genetic marker for MCI in patients with T2D.
摘要
目的
常见的单核苷酸多态性 rs10830963 与 2 型糖尿病（T2D）的风险相关。在这里，我们研究了该基因变异与 T2D 患者心肌梗死（MCI）风险之间的关系。MCI 是此类人群死亡和残疾的主要原因。
研究设计和方法
使用英国生物库队列的数据，以检验 rs10830963 与 13655 例可能患有 T2D 的参与者在 6.8 年的随访期间发生 MCI（致命和非致命）的发生率之间的关系。
结果
在加性遗传模型下，基因中的 rs10830963 变异与 6.8 年随访期间发生 MCI 的风险呈正相关（每个 G 等位基因的校正风险比为 1.19 [95%CI 1.02, 1.40]， = 0.03）。
结论
rs10830963 多态性可能是 T2D 患者 MCI 的有用遗传标志物。
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