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两种治疗性超声方案对严重骨缺损再生效果的比较分析

Comparative Analysis of the Effect of Two Therapeutic Ultrasound Protocols for Regeneration of a Critical Bone Defect.

作者信息

Daltro Ana Flávia Calmon, Barreto Isabela Cerqueira, Almeida Renata Dos Santos, Ribeiro Iorrana Índira Dos Anjos, Barbosa Junior Aryon de Almeida, Rosa Fabiana Paim

机构信息

Laboratório de Bioengenharia Tecidual e Biomateriais (LBTB), Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil.

Departamento de Biofunção, Laboratório de Bioengenharia Tecidual e Biomateriais (LBTB), Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil.

出版信息

Rev Bras Ortop (Sao Paulo). 2020 Jun;55(3):278-283. doi: 10.1055/s-0039-3402457. Epub 2020 Feb 27.

DOI:10.1055/s-0039-3402457
PMID:32616971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7316535/
Abstract

To compare the effect of two therapeutic ultrasound protocols, with different times of exposure in the regeneration of critical bone defect.  Forty-five male rats were distributed among three experimental groups: therapeutic ultrasound group 5 minutes (TUG 5); therapeutic ultrasound group 10 minutes (TUG 10); and control group (CG). In all groups, a critical bone defect of 8.5 mm diameter was made in the calvaria region. The protocol was initiated on the 1 postoperative day in TUGs 5 and 10, with therapeutic ultrasound at the frequency of 1.0 MHz, pulsed mode, five times a week, at periods of 15, 30, and 60 days.  Among the experimental groups, the highest volume of neoformation of osteoid matrix took place in the TUG 10 group followed by TUG 5, when compared with the CG group, in which the neoformation was restricted to the border region. The use of ultrasound promoted an increase in the thickness of the conjunctive matrix, proliferation of capillaries, alignment of the collagen fibers, reduction of edema and inflammatory process, being more significant in the 10-minutes time period.  Therapeutic ultrasound stimulated the repair of a critical bone defect, and the longer exposure time promoted greater osteogenic stimulation.

摘要

为比较两种不同暴露时间的治疗性超声方案在临界骨缺损再生中的效果。45只雄性大鼠被分为三个实验组：5分钟治疗性超声组（TUG 5）；10分钟治疗性超声组（TUG 10）；以及对照组（CG）。在所有组中，于颅骨区域制造直径为8.5毫米的临界骨缺损。TUG 5组和TUG 10组在术后第1天开始方案，采用1.0兆赫频率的治疗性超声，脉冲模式，每周5次，持续15、30和60天。在实验组中，与CG组相比，类骨质基质新形成量最高的是TUG 10组，其次是TUG 5组，CG组的新形成仅限于边缘区域。超声的使用促进了结缔组织基质厚度的增加、毛细血管的增殖、胶原纤维的排列、水肿和炎症过程的减轻，在10分钟时间段更为显著。治疗性超声刺激了临界骨缺损的修复，较长的暴露时间促进了更大的成骨刺激。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/5430d8035326/10-1055-s-0039-3402457-i180467pt-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/a3b05adeaad0/10-1055-s-0039-3402457-i180467en-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/4e644eca25b1/10-1055-s-0039-3402457-i180467en-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/451df66b7f18/10-1055-s-0039-3402457-i180467en-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/f2a5501a122b/10-1055-s-0039-3402457-i180467en-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/bc13c7c3332e/10-1055-s-0039-3402457-i180467en-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/a7f817a94832/10-1055-s-0039-3402457-i180467pt-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/dc7b77347f9c/10-1055-s-0039-3402457-i180467pt-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/6f4240f6f859/10-1055-s-0039-3402457-i180467pt-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/8caf12fb4e32/10-1055-s-0039-3402457-i180467pt-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/5430d8035326/10-1055-s-0039-3402457-i180467pt-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/a3b05adeaad0/10-1055-s-0039-3402457-i180467en-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/4e644eca25b1/10-1055-s-0039-3402457-i180467en-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/451df66b7f18/10-1055-s-0039-3402457-i180467en-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/f2a5501a122b/10-1055-s-0039-3402457-i180467en-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/bc13c7c3332e/10-1055-s-0039-3402457-i180467en-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/a7f817a94832/10-1055-s-0039-3402457-i180467pt-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/dc7b77347f9c/10-1055-s-0039-3402457-i180467pt-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/6f4240f6f859/10-1055-s-0039-3402457-i180467pt-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/8caf12fb4e32/10-1055-s-0039-3402457-i180467pt-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d1/7316535/5430d8035326/10-1055-s-0039-3402457-i180467pt-5.jpg

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