Faculty of Medicine of Sfax, Avenue Majida Bouleila, Sfax 3029, Tunisia.
Physiological Investigations, Habib Bourguiba University Hospital, Route de L'Ain, Sfax 3000, Tunisia.
Pain Res Manag. 2020 Jun 16;2020:7408508. doi: 10.1155/2020/7408508. eCollection 2020.
The management of neuropathic pain remains complex, generally because of the psychiatric comorbidity that is often underdiagnosed. The objectives of our work were to determine the link between depression and the characteristics of NP on the one hand and quality of life on the other hand, in a sample of subjects consulting for neuropathic pain (NP) regardless of etiology.
We conducted a cross-sectional study involving 61 neuropathic pain consulting patients in whom we assessed five parameters, namely, neuropathic pain based on DN4, pain intensity using EVA, anxiety, and depression according to the HADS and quality of life.
The study population mean age was 52.71 ± 14.29 years while the sex ratio (m/f) was 0.52. The neuropathic pain's most common etiologies were postherpetic pain, carpal tunnel syndrome, and diabetic neuropathy. Depression and anxiety prevailed by 65.6% and 73.7%, respectively. The quality of life was impaired with average SF-12 physical and mental scores of 33.76 ± 8.03 and 37.78 ± 11.52, respectively. The overall mean BPI score was 5.53 ± 1.76. Patients with high DN4 scores were significantly more depressed (=0.025). A significantly positive association was found between the depression score and the pain intensity (=0.001, = 0.41). Depressed subjects had a poor quality of life according to SF-12 and BPI.
Given the depressive comorbidity impact on the neuropathic pain components as well as the quality of life, screening for this comorbidity should be part of the baseline ND assessment.
神经病理性疼痛的治疗仍然很复杂，通常是因为经常被漏诊的精神共病。我们工作的目的是确定一方面抑郁与 NP 特征之间的联系，另一方面是生活质量之间的联系，研究对象为患有神经病理性疼痛（NP）的患者，无论病因如何。
我们进行了一项横断面研究，共纳入 61 名接受神经病理性疼痛咨询的患者，评估了 5 个参数，即基于 DN4 的神经病理性疼痛、EVA 测量的疼痛强度、根据 HADS 评估的焦虑和抑郁以及生活质量。
研究人群的平均年龄为 52.71 ± 14.29 岁，男女比例为 0.52。最常见的神经病理性疼痛病因是带状疱疹后神经痛、腕管综合征和糖尿病性神经病。抑郁和焦虑分别占 65.6%和 73.7%。生活质量受损，SF-12 身体和心理评分平均为 33.76 ± 8.03 和 37.78 ± 11.52。总体 BPI 评分平均为 5.53 ± 1.76。DN4 评分高的患者抑郁程度明显更高（=0.025）。抑郁评分与疼痛强度之间存在显著正相关（=0.001，=0.41）。抑郁患者的 SF-12 和 BPI 生活质量较差。
鉴于抑郁共病对神经病理性疼痛的各个组成部分以及生活质量的影响，这种共病的筛查应作为 ND 评估的基线检查的一部分。
