Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Radiation Oncology, University of Minnesota, MN 55455, USA.
Future Oncol. 2020 Oct;16(30):2445-2455. doi: 10.2217/fon-2020-0558. Epub 2020 Jul 3.
Glioblastoma is the most common primary malignant neoplasm of the central nervous system in adults. Standard of care is resection followed by chemo-radiation therapy. Despite this aggressive approach, >80% of glioblastomas recur in proximity to the resection cavity. Brachytherapy is an attractive strategy for improving local control. GammaTile is a newly US FDA-cleared device which incorporates Cs radiation emitting seeds in a resorbable collagen-based carrier tile for surgically targeted radiation therapy to achieve highly conformal radiation at the time of surgery. Embedding encapsulated Cs radiation emitter seeds in collagen-based tiles significantly lowers the technical barriers associated with traditional brachytherapy. In this review, we highlight the potential of surgically targeted radiation therapy and the currently available data for this novel approach.
胶质母细胞瘤是成人中枢神经系统最常见的原发性恶性肿瘤。标准治疗方法是切除后进行化疗和放疗。尽管采用了这种积极的治疗方法，但超过 80%的胶质母细胞瘤在切除部位附近复发。近距离放射治疗是一种提高局部控制率的有吸引力的策略。GammaTile 是一种新的获得美国食品和药物管理局批准的设备，它将 Cs 辐射发射种子嵌入可吸收的胶原载体 tile 中，用于手术靶向放射治疗，以在手术时实现高度适形的放射。将封装的 Cs 辐射发射器种子嵌入胶原 tile 中，显著降低了与传统近距离放射治疗相关的技术障碍。在这篇综述中，我们强调了手术靶向放射治疗的潜力和这种新方法的现有数据。
