简化口服胰腺功能试验
Simplified oral pancreatic function test.
作者信息
Puntis J W, Berg J D, Buckley B M, Booth I W, McNeish A S
机构信息
Institute of Child Health, University of Birmingham, Birmingham Children's Hospital.
出版信息
Arch Dis Child. 1988 Jul;63(7):780-4. doi: 10.1136/adc.63.7.780.
The standard Bentiromide test and a new modified test using p-aminosalicylic acid (PAS) as a pharmacokinetic marker for p-aminobenzoic acid (PABA) have been evaluated in the detection of pancreatic exocrine insufficiency in children. The conventional two day test using a colorimetric assay for urinary PABA discriminated poorly between five children with pancreatic insufficiency and 13 others with normal pancreatic function. Two further groups of patients, comprising 28 with pancreatic exocrine insufficiency and 20 with normal pancreatic function underwent the modified test, and urine samples were analysed by high performance liquid chromatography. The results showed a complete separation between groups. The use of PAS eliminates a number of sources of error inherent in a two day Bentiromide test and provides a simplified and accurate diagnostic test for pancreatic insufficiency. The PABA-PAS modified test enables collection of the urine to be done during a single six hour period.
在儿童胰腺外分泌功能不全的检测中，对标准的苯替酪胺试验以及一种使用对氨基水杨酸（PAS）作为对氨基苯甲酸（PABA）药代动力学标志物的新改良试验进行了评估。使用比色法检测尿中PABA的传统两天试验，在5例胰腺功能不全儿童和其他13例胰腺功能正常的儿童之间鉴别能力较差。另外两组患者，包括28例胰腺外分泌功能不全患者和20例胰腺功能正常的患者接受了改良试验，并通过高效液相色谱法分析尿样。结果显示两组之间完全分离。PAS的使用消除了两天苯替酪胺试验中固有的一些误差来源，并为胰腺功能不全提供了一种简化且准确的诊断试验。PABA-PAS改良试验能够在单个6小时时间段内完成尿液采集。
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