使用苯替酪胺和对氨基水杨酸在同一天进行检测所测定的外分泌胰腺功能。

Exocrine pancreatic function as determined in a same-day test with use of bentiromide and p-aminosalicylic acid.

作者信息

Berg J D, Chesner I M, Allen-Narker R A, Buckley B M, Lawson N

出版信息

Clin Chem. 1986 Jun;32(6):1010-2.

Abstract

We describe a new approach to the bentiromide test of exocrine pancreatic function, p-Aminosalicylic acid (PAS), a compound closely related to the bentiromide fragment p-aminobenzoic acid (PABA), is used as a marker of the pharmacokinetic behavior of PABA to derive a PABA excretion index. This index is identical to that derived with [14C]-PABA. Concentrations of both PABA and PAS are measured in urine by "high-performance" liquid chromatography, which avoids the drug interferences encountered with established assays of PABA. We discuss the practical and diagnostic advantages of this new approach to the bentiromide test.

摘要

我们描述了一种用于外分泌胰腺功能苯替酪胺试验的新方法。对氨基水杨酸（PAS）是一种与苯替酪胺片段对氨基苯甲酸（PABA）密切相关的化合物，用作PABA药代动力学行为的标志物，以得出PABA排泄指数。该指数与用[14C]-PABA得出的指数相同。通过“高效”液相色谱法测量尿液中PABA和PAS的浓度，这避免了在已有的PABA检测方法中遇到的药物干扰。我们讨论了这种苯替酪胺试验新方法的实际和诊断优势。