Csizmadia Tamás, Juhász Gábor
Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.
Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary; Institute of Genetics, Biological Research Centre, Szeged, Hungary.
Prog Mol Biol Transl Sci. 2020;172:239-255. doi: 10.1016/bs.pmbts.2020.02.002. Epub 2020 Feb 29.
Autophagic-lysosomal degradation is essential for the maintenance of normal homeostasis in eukaryotic cells. Several types of such self-degradative and recycling pathways have been identified. From these, probably the least known autophagic process is crinophagy, during which unnecessary or obsolete secretory granules directly fuse with late endosomes/lysosomes as a means of rapid elimination of unused secretory material from the cytoplasm. This process was identified in 1966, but we are only beginning to understand the molecular mechanisms and regulation of crinophagy. In this review, we summarize the current examination methods and possible model systems, discuss the recently identified factors that are required for crinophagy, and give an overview of the potential medical relevance of this process.
自噬性溶酶体降解对于真核细胞维持正常的内环境稳定至关重要。已经鉴定出几种这样的自我降解和循环途径。其中，可能最不为人所知的自噬过程是分泌自噬，在此过程中，不必要或过时的分泌颗粒直接与晚期内体/溶酶体融合，作为从细胞质中快速清除未使用的分泌物质的一种方式。这个过程在1966年被发现，但我们才刚刚开始了解分泌自噬的分子机制和调控。在这篇综述中，我们总结了当前的检测方法和可能的模型系统，讨论了最近鉴定出的分泌自噬所需的因子，并概述了这一过程潜在的医学相关性。
