Department of Pathology, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, 251 East Huron Street, Feinberg 7-230, Chicago, IL 60611, USA.
Department of Pathology, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, 251 East Huron Street, Feinberg 7-230, Chicago, IL 60611, USA.
Clin Liver Dis. 2020 Aug;24(3):361-372. doi: 10.1016/j.cld.2020.04.001. Epub 2020 May 11.
Liver biopsy and histologic examination are the mainstay for diagnosing liver diseases, despite advances in imaging and molecular procedures. Liver biopsy can provide useful information regarding the structural integrity and type and degree of injury, disease activity, response to treatment, progression of disease and degree/staging of fibrosis. Liver biopsies evaluate acute and chronic liver diseases, and mass-forming lesions. The role of the pathologist is to integrate clinical, serologic, and biochemical data with morphologic changes and provide a comprehensive diagnosis. This review focuses on basic principles necessary for proper interpretation of liver biopsy specimens in patients with chronic liver disease.
肝活检和组织学检查是诊断肝脏疾病的主要方法，尽管影像学和分子方法有所进展。肝活检可以提供有关肝脏结构完整性以及损伤的类型和程度、疾病活动度、治疗反应、疾病进展和纤维化程度/分期的有用信息。肝活检可评估急性和慢性肝病以及形成肿块的病变。病理学家的作用是将临床、血清学和生化数据与形态变化相结合，并提供全面的诊断。本文重点介绍了慢性肝病患者肝活检标本正确解读所需的基本原则。
