基因多态性与 MMP-2 和 MMP-9 的循环水平：对其在乳腺癌风险中的作用的综述。
Gene Polymorphisms and Circulating Levels of MMP-2 and MMP-9: A Review of Their Role in Breast Cancer Risk.
机构信息
Division of Oncology, CHU de Québec-Université Laval Research Center, Quebec City, QC, Canada.
Cancer Research Center - Laval University, Quebec City, QC, Canada.
出版信息
Anticancer Res. 2020 Jul;40(7):3619-3631. doi: 10.21873/anticanres.14351.
MMP-2 and MMP-9 genes have been suggested to play a role in breast cancer. Their functions have been associated with invasion and metastasis of breast cancer; however, their involvement in the development of the disease is not well-established. Herein, we reviewed the literature investigating the association between circulating levels and polymorphisms of MMP-2 and MMP-9 and breast cancer risk. Various studies report conflicting results regarding the relationship of polymorphisms in MMP-2 and MMP-9 and breast cancer risk. Nevertheless, it appears that the T allele in rs243865 and rs2285053 in MMP-2 are associated with reduced risk of breast cancer. In addition, high levels of latent form and low levels of active form of MMP-2 were observed in breast cancer patients compared to controls. For MMP-9, high latent levels and low total levels were found in breast cancer patients compared to controls. Additional studies are needed to comprehend the role of these genes in breast carcinogenesis.
基质金属蛋白酶-2（MMP-2）和 MMP-9 基因被认为在乳腺癌中发挥作用。它们的功能与乳腺癌的侵袭和转移有关；然而，它们在疾病发展中的作用尚未得到充分证实。在此，我们综述了关于循环 MMP-2 和 MMP-9 水平和多态性与乳腺癌风险之间关系的文献。关于 MMP-2 和 MMP-9 多态性与乳腺癌风险的关系，各种研究报告的结果相互矛盾。然而，MMP-2 中的 rs243865 和 rs2285053 的 T 等位基因似乎与乳腺癌风险降低相关。此外，与对照组相比，乳腺癌患者中 MMP-2 的潜伏形式水平较高，活性形式水平较低。对于 MMP-9，与对照组相比，乳腺癌患者中潜伏水平较高，总水平较低。需要进一步的研究来理解这些基因在乳腺癌发生中的作用。
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