Department of Oncology, Dell Medical School, Livestrong Cancer Institutes, The University of Texas at Austin, Austin, TX, U.S.A.
Nephrology Unit, Salerno University Hospital, Salerno, Italy.
Anticancer Res. 2020 Jul;40(7):4017-4022. doi: 10.21873/anticanres.14396.
BACKGROUND/AIM: Squamous cell carcinoma (SCC) is highly prevalent in kidney transplant patients (KT). It is characterized by the presence of an inflammatory infiltrate. In this study, we examined the presence of similar infiltrates in intact skin, which could be regarded as a precancerous step.
We retrospectively analyzed skin biopsies of 19 non-transplanted patients with a diagnosis of SCC or basal cell carcinoma (BCC) and 17 KT with either SCC or BCC.
KT showed increased inflammatory infiltrate in the subepithelial region, compared to non-transplanted patients. The density of basal cell nuclei was also different among the four groups with an interaction effect between tumor type and transplantation. The extent of inflammatory infiltrates did not correlate with the eGFR and proteinuria.
KT with a non-melanoma skin cancer show increased intact skin inflammatory infiltrate and alterations in the density of the basal cell layer compared to non-transplanted patients.
背景/目的：鳞状细胞癌（SCC）在肾移植患者（KT）中非常普遍。其特征是存在炎症浸润。在这项研究中，我们检查了完整皮肤中是否存在类似的浸润，这可能被视为癌前步骤。
我们回顾性分析了 19 名非移植患者 SCC 或基底细胞癌（BCC）的皮肤活检和 17 名 KT 患者 SCC 或 BCC 的皮肤活检。
与非移植患者相比，KT 在表皮下区域显示出更多的炎症浸润。基底细胞核的密度在四组之间也不同，存在肿瘤类型和移植之间的交互作用。炎症浸润的程度与 eGFR 和蛋白尿无关。
与非移植患者相比，患有非黑色素瘤皮肤癌的 KT 显示出更多的完整皮肤炎症浸润和基底细胞层密度的改变。
