Department of Surgery, Division of Breast and Endocrine Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Department of Breast Surgery, Yao Municipal Hospital, Yao, Japan.
Anticancer Res. 2020 Jul;40(7):4147-4156. doi: 10.21873/anticanres.14414.
BACKGROUND/AIM: We investigated the efficacy of neutrophil-to-lymphocyte ratio (NLR), absolute lymphocyte count (ALC), and C-reactive protein (CRP) in predicting overall survival of metastatic breast cancer patients treated with eribulin.
Overall, 74 patients treated with eribulin were enrolled and their baseline levels of NLR, ALC, and CRP retrieved. Cutoff values of NLR, ALC, and CRP were set at 3.0, 1500/μl, and 0.3 mg/dl, respectively. Overall survival (OS) was compared according to marker levels.
The OS of NLR-low, ALC-high, and CRP-low groups at baseline was significantly longer than that of NLR-high, ALC-low, and CRP-high groups (p=0.0027, p=0.0013, and p=0.0164, respectively). The combination of ALC and CRP was significantly associated with OS by multivariate analysis (p=0.048).
Baseline levels of NLR, ALC, and CRP were significantly associated with OS in patients treated with eribulin. The combination of ALC and CRP improved the predictive efficacy compared to individual markers.
背景/目的：我们研究了中性粒细胞与淋巴细胞比值（NLR）、绝对淋巴细胞计数（ALC）和 C 反应蛋白（CRP）在预测接受艾立布林治疗的转移性乳腺癌患者总生存期方面的疗效。
共纳入 74 例接受艾立布林治疗的患者，并回顾其 NLR、ALC 和 CRP 的基线水平。NLR、ALC 和 CRP 的截断值分别设定为 3.0、1500/μl 和 0.3mg/dl。根据标志物水平比较总生存期（OS）。
NLR 低、ALC 高和 CRP 低组的 OS 明显长于 NLR 高、ALC 低和 CRP 高组（p=0.0027、p=0.0013 和 p=0.0164）。多因素分析显示，ALC 和 CRP 的联合与 OS 显著相关（p=0.048）。
NLR、ALC 和 CRP 的基线水平与接受艾立布林治疗的患者的 OS 显著相关。与单独标志物相比，ALC 和 CRP 的联合提高了预测疗效。
