Department of Transplantation Medicine, Oslo University Hospital, Sognsvannsveien 20, 0372, Oslo, Norway.
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Langenbecks Arch Surg. 2020 Aug;405(5):657-664. doi: 10.1007/s00423-020-01917-9. Epub 2020 Jul 3.
To evaluate the long-term outcomes of percutaneous transhepatic stent placement for portal vein (PV) stenosis after liver transplantation (LT) and hepato-pancreato-biliary (HPB) surgery.
Retrospective study of 455 patients who underwent LT and 522 patients who underwent resection of the pancreatic head between June 2011 and February 2016. Technical success, clinical success, patency, and complications were evaluated for both groups.
A total of 23 patients were confirmed to have postoperative PV stenosis and were treated with percutaneous transhepatic PV stent placement. The technical success rate was 100%, the clinical success rate was 80%, and the long-term stent patency was 91.3% for the entire study population. Two procedure-related hemorrhages and two early stent thromboses occurred in the HPB group while no complications occurred in the LT group. A literature review of selected studies reporting PV stent placement for the treatment of PV stenosis after HPB surgery and LT showed a technical success rate of 78-100%, a clinical success rate of 72-100%, and a long-term patency of 57-100%, whereas the procedure-related complication rate varied from 0-33.3%.
Percutaneous transhepatic PV stent is a safe and effective treatment for postoperative PV stenosis/occlusion in patients undergoing LT regardless of symptoms. Due to increased risk of complications, the indication for percutaneous PV stent placement after HPB surgery should be limited to patients with clinical symptoms after an individual assessment.
评估经皮经肝支架置入术治疗肝移植(LT)和肝胆胰(HPB)手术后门静脉(PV)狭窄的长期疗效。
回顾性分析 2011 年 6 月至 2016 年 2 月期间 455 例行 LT 患者和 522 例行胰头切除术患者的临床资料。评估两组患者的技术成功率、临床成功率、通畅率和并发症。
共 23 例患者术后被证实存在 PV 狭窄,采用经皮经肝 PV 支架置入术治疗。全组患者的技术成功率为 100%,临床成功率为 80%,长期支架通畅率为 91.3%。HPB 组发生 2 例与操作相关的出血和 2 例早期支架内血栓形成,LT 组无并发症发生。对选择性报道 HPB 手术后和 LT 后 PV 支架治疗 PV 狭窄的文献进行回顾,结果显示技术成功率为 78%-100%,临床成功率为 72%-100%,长期通畅率为 57%-100%,而与操作相关的并发症发生率为 0%-33.3%。
经皮经肝 PV 支架置入术是治疗 LT 后无论有无症状的 PV 狭窄/闭塞的安全有效的方法。由于并发症风险增加,HPB 手术后经皮 PV 支架置入的适应证应限于经个体评估后有临床症状的患者。