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术中放置支架治疗小儿活体肝移植急性门静脉并发症

Intraoperative stent placement for the treatment of acute portal vein complications in pediatric living donor liver transplantation.

作者信息

Czerwonko Matias E, Pekolj Juan, Mattera Juan, Peralta Oscar A, García-Mónaco Ricardo D, de Santibañes Eduardo, de Santibañes Martín

机构信息

Department of General Surgery, Division of HPB Surgery and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Juan D. Peron 4190, C1181ACH, Buenos Aires, Argentina.

Department of Radiology, Division of Interventional Radiology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

出版信息

Langenbecks Arch Surg. 2019 Feb;404(1):123-128. doi: 10.1007/s00423-018-1741-7. Epub 2018 Dec 15.

DOI:10.1007/s00423-018-1741-7
PMID:30554377
Abstract

PURPOSE

Pediatric living donor liver transplantation (LDLT) in low weight recipients remains one of the most complex surgical procedures, with portal vein (PV) complications occurring in up to 19% of cases. When decreased PV flow is diagnosed intra- or perioperatively, intraoperative stent placement is a good substitute for surgical adjustment. Still, at the present moment, little is known about the technical feasibility, safety, efficacy, and long-term outcome of intraoperative stenting in LDLT.

METHODS

Between 2006 and 2017, seven pediatric recipients underwent PV stent placement during the transplant or in the immediate post-operative setting. Preoperative, operative, and post-operative parameters were documented retrospectively.

RESULTS

In total, nine stents were placed in seven patients. Procedures were technically successful in all patients. During the mean imaging follow-up period of 1313 days, none of the patients showed PV abnormality and PV stent remained patent throughout the post-transplant course. There were no deaths or graft loses during the follow-up period.

CONCLUSIONS

Intraoperative stenting through the inferior mesenteric vein approach offers both a high feasibility and satisfactory results, with the potential for excellent long-term primary patency despite continued growth in children.

摘要

目的

低体重受者的小儿活体肝移植(LDLT)仍然是最复杂的外科手术之一,门静脉(PV)并发症发生率高达19%。当在术中或围手术期诊断出门静脉血流减少时,术中放置支架是手术调整的良好替代方法。然而,目前对于小儿活体肝移植术中支架置入的技术可行性、安全性、有效性和长期结果知之甚少。

方法

2006年至2017年间,7名小儿受者在移植期间或术后即刻接受了门静脉支架置入。回顾性记录术前、术中和术后参数。

结果

7名患者共置入9个支架。所有患者手术均获技术成功。在平均1313天的影像随访期内,所有患者均未出现门静脉异常,门静脉支架在移植后的整个过程中均保持通畅。随访期间无死亡或移植物丢失。

结论

通过肠系膜下静脉途径进行术中支架置入具有很高的可行性和令人满意的结果,尽管儿童持续生长,但仍有可能实现出色的长期原发性通畅。

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Ann Surg. 2018 Mar;267(3):e42-e44. doi: 10.1097/SLA.0000000000002333.
2
Section 6. Management of extensive nontumorous portal vein thrombosis in adult living donor liver transplantation.第六节:成人活体肝移植中广泛非肿瘤性门静脉血栓的处理。
Transplantation. 2014 Apr 27;97 Suppl 8:S23-30. doi: 10.1097/01.tp.0000446270.20934.05.
3
Transplantation with hyper-reduced liver grafts in children under 10 kg of weight.
终末期泡型肝包虫病合并海绵样变行离体肝切除及自体肝移植后门静脉狭窄的介入治疗成功
Ann Transplant. 2024 Sep 24;29:e944851. doi: 10.12659/AOT.944851.
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Surgical strategies to treat portal vein thrombosis during adult liver transplantation.成人肝移植中治疗门静脉血栓形成的手术策略。
Langenbecks Arch Surg. 2023 Oct 13;408(1):399. doi: 10.1007/s00423-023-03141-7.
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Balloon angioplasty versus stent placement for the treatment of portal vein stenosis in children: a single center experience.球囊血管成形术与支架置入术治疗儿童门静脉狭窄:单中心经验。
Pediatr Radiol. 2023 Aug;53(9):1885-1893. doi: 10.1007/s00247-023-05674-x. Epub 2023 May 6.
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The Application of Interventional Radiology in Living-Donor Liver Transplantation.介入放射学在活体肝移植中的应用。
Korean J Radiol. 2021 Jul;22(7):1110-1123. doi: 10.3348/kjr.2020.0718. Epub 2021 Mar 9.
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在体重不足 10 公斤的儿童中进行超小型肝移植物移植。
Langenbecks Arch Surg. 2013 Jan;398(1):79-85. doi: 10.1007/s00423-012-1020-y. Epub 2012 Oct 24.
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