Department of Physics and Nanotechnology, SRM Institute of Science and Technology, Chengalpattu District, Tamil Nadu, 603 203, India.
Centre for Nanoscience and Technology, Anna University, Chennai, Tamil Nadu, India.
J Fluoresc. 2020 Sep;30(5):1075-1083. doi: 10.1007/s10895-020-02578-z. Epub 2020 Jul 3.
Semiconducting nanoparticles with luminescent properties are used as detection probes and drug carriers in in-vitro and in-vivo analysis. ZnO nanoparticles, due to its biocompatibility and low cost, have shown potential application in bioimaging and drug delivery. Thus, ZnO/SiO core/shell nanoparticle was synthesised by wet chemical method for fluorescent probing and drug delivery application. The synthesised core/shell nanomaterial was characterized using XRD, FTIR, UV-VIS spectroscopy, Raman spectroscopy, TEM and PL analysis. The silicon shell enhances the photoluminescence and aqueous stability of the pure ZnO nanoparticles. The porous surface of the shell acts as a carrier for sustained release of curcumin. The synthesized core/shell particle shows high cell viability, hemocompatibility and promising florescent property. Graphical Abstract.
具有发光性能的半导体纳米粒子在体外和体内分析中用作检测探针和药物载体。氧化锌纳米粒子由于其生物相容性和低成本，在生物成像和药物传递方面显示出潜在的应用。因此，通过湿化学方法合成了 ZnO/SiO 核/壳纳米粒子，用于荧光探测和药物输送应用。使用 XRD、FTIR、UV-VIS 光谱、拉曼光谱、TEM 和 PL 分析对合成的核/壳纳米材料进行了表征。硅壳增强了纯 ZnO 纳米粒子的光致发光和水稳定性。壳的多孔表面可作为姜黄素持续释放的载体。合成的核/壳粒子表现出高细胞活力、血液相容性和有前途的荧光特性。
