Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Yuanmingyuan West Road 2, Beijing, 100193, People's Republic of China.
Environ Sci Pollut Res Int. 2020 Oct;27(30):38056-38063. doi: 10.1007/s11356-020-09815-9. Epub 2020 Jul 3.
As an agricultural fungicide, penconazole (PEN) is widely used and has adverse effects on various organisms. In order to evaluate the ecological safety risks of PEN, the bioaccumulation and toxic effects of PEN in earthworms were studied. Specifically, the results show that the biota-sediment accumulation factor (BSAF) of PEN in earthworms reaches its maximum within 1 day, and then decreases slowly. It reached its lowest value after 14 days of PEN exposure and then rose again. In addition, oxidative stress and metabolic disorder of the earthworm with PEN exposure were assessed. After PEN exposure, the related indicators of oxidative stress involved in the activities of SOD and CAT and the contents of GSH and MDA all changed significantly in earthworms. Moreover, metabolomics analysis of earthworms showed disturbed metabolic profiles following PEN exposure. Respectively, PEN exposure significantly altered the relative abundances of 14 metabolites in earthworms. In general, exposure to PEN caused oxidative stress and metabolic profile disorders of earthworms. The results of this study will be helpful for further evaluation of soil ecological security of PEN.
作为一种农用杀菌剂，戊唑醇（PEN）被广泛使用，对各种生物都有不良影响。为了评估 PEN 的生态安全风险，研究了 PEN 在蚯蚓中的生物积累和毒性作用。具体而言，研究结果表明，PEN 在蚯蚓中的生物浓缩因子（BSAF）在 1 天内达到最大值，然后缓慢下降。在 PEN 暴露 14 天后达到最低值，然后再次上升。此外，还评估了 PEN 暴露对蚯蚓的氧化应激和代谢紊乱的影响。PEN 暴露后，蚯蚓中涉及 SOD 和 CAT 活性的氧化应激相关指标以及 GSH 和 MDA 的含量均发生显著变化。此外，蚯蚓的代谢组学分析表明，PEN 暴露后其代谢谱受到干扰。分别地，PEN 暴露显著改变了蚯蚓中 14 种代谢物的相对丰度。总的来说，PEN 暴露导致蚯蚓发生氧化应激和代谢谱紊乱。本研究结果将有助于进一步评估 PEN 对土壤生态安全的影响。
